BACKGROUND Widespread residential pesticide use throughout the United States has resulted in ubiquitous, low-level pesticide exposure. The mix of active pesticide ingredients is changing in response to 2000-2001 regulations restricting use of the organophosphorus insecticides chlorpyrifos and diazinon. OBJECTIVES We aimed to determine the impact of U.S. Environmental Protection Agency regulat...

Hydrolytic metabolism of pyrethroid insecticides in humans is one of the major catabolic pathways that clear these compounds from the body. Rodent models are often used to determine the disposition and clearance rates of these esterified compounds. In this study the distribution and activities of esterases that catalyze pyrethroid metabolism have been investigated in vitro using several human a...

Pyrethroid insecticides have been widely detected in sediments at concentrations that can cause toxicity to aquatic organisms. Desorption rates play an important role in determining the bioavailability of hydrophobic organic compounds, such as pyrethroids, because these compounds are more likely to be sorbed to solids in the environment, and times to reach sorptive equilibrium can be long. In t...

Here we report a study of the 204 P450 genes in the whole genome sequence of larvae and adult Culex quinquefasciatus mosquitoes. The expression profiles of the P450 genes were compared for susceptible (S-Lab) and resistant mosquito populations, two different field populations of mosquitoes (HAmCq and MAmCq), and field parental mosquitoes (HAmCq(G0) and MAmCq(G0)) and their permethrin selected o...

INTRODUCTION AND OBJECTIVE Prevention of tick borne diseases in forestry workers is essentially based on the use of appropriate clothing. The objective of this pragmatic, randomized, controlled trial was to assess the potential benefit of permethrin-treated working trousers for the prevention of tick infestation during forestry work. MATERIALS AND METHODS N=164 male forestry workers were equi...

Impregnated bednets can be considered a major tool for reducing Anopheles bites, malaria morbi dity and overall mortality. The resistance of Anopheles gambiae to pyrethroids used to impregnate bednets and curtains has already been noted in the urban area of Cotonou in Benin (18, 21). In this study, we wished to find out if the resistance observed in Cotonou is localized only in this town or is ...

Permethrin is the most popular synthetic pyrethroid insecticide in agriculture and public health. For the development of the enzyme-linked immunosorbent assay (ELISA) to evaluate human exposure to permethrin, the glycine conjugate (DCCA-glycine) of a major metabolite, cis/trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane-1-carboxylic acid (DCCA), of permethrin was established as the target a...

To gain valuable insights into the gene interaction and the complex regulation system involved in the development of insecticide resistance in mosquitoes Culex quinquefasciatus, we conducted a whole transcriptome analysis of Culex mosquitoes following permethrin selection. Gene expression profiles for the lower resistant parental mosquito strain HAmCq(G0) and their permethrin-selected high resi...

Member states of the European Union are required to ensure initiation monitoring programs verify honey bee exposure pesticides, where and as appropriate. Based on 620 samples dead bees—42 pollen, 183 32 vegetables—we highlighted presence, analyzed by liquid gas chromatography coupled with tandem mass spectrometric detection, many active substances, mainly tau-fluvalinate, piperonyl butoxide, ch...