background: considering the role of matrix metalloproteinase-3 (mmp-3) and tissue inhibitor of matrix metalloproteinase-1 (timp-1) in the pathogenesis of periodontitis, the present study is to estimate the levels of mmp-3 and timp-1 in gingival crevicular fluid (gcf) in periodontal health, disease and to evaluate the effect of periodontal therapy on mmp-3 and timp-1 concentrations in gcf. mater...

BACKGROUND Diabetes mellitus is a metabolic disorder characterized by hyperglycemia. The abnormal glucose metabolism results from defects in insulin production or insulin action, or both. For decades, it was suspected that diabetes contributed to poorer oral health and the increased frequency of periodontitis. More recently it was found that periodontitis could adversely affect glycemic control...

Background: Observations from several epidemiologic and clinical studies suggest that psychological stress has a role in the etiology and progression of periodontal diseases (PD). The aim of the present study was to systematically analyze the influence of stress on periodontal disease reported in various case control, cross sectional and prospective clinical trials. The focused question analyze...

background and aims. traditional methods of diagnosing periodontal diseases have their limitations, which include inability to provide information about the recent activity of the disease and difficulty in diagnosing the disease at an early stage when clinical changes have not started. this has necessitated the use of biomarkers designed to overcome these short-comings. materials and methods. a...

BACKGROUND AND OBJECTIVE It was the purpose of this study to examine the relationship between periodontal diseases and melatonin level. MATERIAL AND METHODS Forty-six patients with periodontal disease, together with 26 age- and gender-matched healthy controls, were included. Periodontal status was assessed using the Community Periodontal Index. Plasma and salivary melatonin levels were determ...

BACKGROUND Periodontitis is the most common chronic inflammatory condition worldwide and is associated with incident coronary disease. HYPOTHESIS We hypothesized that periodontal disease would also be associated with cardiac calcification, a condition which shares many risk factors with atherosclerosis and is considered a marker of subclinical atherosclerosis. METHODS Cross-sectional study ...

Atherosclerosis is the most common cause of myocardial infarction and ischemic stroke. Various risk factors have been identified for atherosclerosis. Recently, bacterial and viral organisms, which are involved in chronic inflammatory processes, have been also implicated in atherosclerosis development. Individuals with a prior history of periodontal diseases and/or tooth loss are considered to be...

To identify the prevalence and risk indicators of periodontal disease in high-school students in Tehran, Islamic Republic of Iran, the periodontal condition of 867 students aged 15-19 years was assessed using the community periodontal index of treatment needs (CPITN). The results showed that 88.7% of these students had less than perfect periodontal health. Multiple regression analysis revealed ...