SOCS1 is an SH2-containing protein that is primarily expressed in thymocytes in a cytokine- and T cell receptor-independent manner. SOCS1 deletion causes perinatal lethality with death by 2-3 weeks. During this period thymic changes include a loss of cellularity and a switch from predominantly CD4+ CD8+ to single positive cells. Peripheral T cells express activation antigens and proliferate to ...

A pregnant woman with inherited thrombophilia (factor II mutation--20210A) had two late pregnancy losses. The first pregnancy was not well documented, but the second pregnancy was complicated by fetal thrombophilia and umbilical artery thrombosis, proven after fetal death. During the third pregnancy enoxaparine was introduced in the therapy and early amniocentesis was performed. Fetal thromboph...

Assessment of risk factors Childhood risk factors were assessed up to 9 years of age: neurodevelopmental characteristics (perinatal insults, gross motor skills, and intelligence quotient); parental characteristics (mother’s internalising symptoms, including depression and anxiety, mother–child interactions, criminal conviction history, and parental disagreement about discipline); family charact...

La pérdida perinatal, genera problemas psicopatológicos en algunas mujeres. Para elaborar el duelo se activan recursos psicológicos, tales como los estilos de afrontamiento. El objetivo del estudio fue determinar la relación entre tipo afrontamiento y intensidad duelo, conocer que resultaron predictores confiables para perinatal. Se realizó un no experimental, transversal, correlacional con 100...

Introduction The incidence of acute appendicitis in pregnancy is 1:2000 (1:700 ÷ 3000); 60% suffer from acute appendicitis in the first half of pregnancy. When perforated appendicitis complicated by diffuse peritonitis, maternal mortality rate reaches 16.7%, with perinatal loss in the 19,4-50%. Explainable limitation application of instrumental diagnostic methods at different stages of pregnanc...

Twin-twin transfusion syndrome (TTTS) affects 10% to 15% of monochorionic pregnancies. In the absences of timely diagnosis and intervention perinatal loss or long term developmental delay can be expected in over 90% of cases. Establishing chorionicity in the first trimester followed by serial ultrasounds beginning at 16 weeks of gestation and intervention with placental laser ablation before th...

Quality control in perinatal education is imperative, with the purpose to deliver a high quality and appropriate healthcare service to the family in the perinatal period. The purpose of this study was to develop valid standards for perinatal education in South Africa. To reach this goal, the study proceeded as follows: Development phase concepts were developed for perinatal education, the conce...

Descriptions of 85 women's feelings about miscarriage at 1, 6, 16, and 52 weeks were inductively coded, rank-ordered, and clustered into 3 responses: healing, actively grieving, and overwhelmed. Women who were actively grieving or overwhelmed at 1 week experienced significantly less distress from 6 weeks on. Responses at 1 week differed with regards to those who had a history of perinatal loss ...