Condensin is a DNA compaction machine that functions in chromosome architecture, nucleolar organization, and chromo­ some segregation (Hirano, 2006). Condensin can introduce su­ percoils and decatenate topologically linked circles. The most prominent sites of condensin localization in the nucleus are the nucleolus, pericentric chromatin, and central axis of condensed metaphase chromosomes. Cond...

Yeast centromeres coordinate their movements C ondensin and cohesin cross-link the pericentromeres of budding yeast chromosomes to coordinate their dynamics during mitosis, Stephens et al. reveal. In budding yeast, each centromere attaches to a single microtubule during metaphase. The pericentric chromatin surrounding each centromere forms a spring that resists the forces pulling it toward the ...

Abstract. In this paper we show that if G is a group acting on a tree X with inversions and if (T Y ) is a fundamental domain for the action of G on X, then there exist a group &tildeG and a tree &tildeX induced by (T Y ) such that &tildeG acts on &tildeX with inversions, G is isomorphic to &tilde G, and X is isomorphic to &tildeX. The pair (&tilde G &tildeX) is called the quasi universal cover...

Chromosomal inversions have been repeatedly involved in local adaptation in a large number of animals and plants. The ecological and behavioral plasticity of Anopheles species-human malaria vectors-is mirrored by high amounts of polymorphic inversions. The adaptive significance of chromosomal inversions has been consistently attested by strong and significant correlations between their frequenc...

Motivation: There are many different forms of genomic structural variation that can be broadly classified into two groups as copy number variation (CNV) and balanced rearrangements. Although many algorithms are now available in the literature that aim to characterize CNVs, discovery of balanced rearrangements (inversions and translocations) remains an open problem. This is mainly because the br...

Chromosomal inversions are a ubiquitous feature of genetic variation. Theoretical models describe several mechanisms by which inversions can drive adaptation and be maintained as polymorphisms. While inversions have been shown previously to be under selection, or contain genetic variation under selection, the specific phenotypic consequences of inversions leading to their maintenance remain unc...

Chromosomal inversions have been an enduring interest of population geneticists since their discovery in Drosophila melanogaster. Numerous lines of evidence suggest powerful selective pressures govern the distributions of polymorphic inversions, and these observations have spurred the development of many explanatory models. However, due to a paucity of nucleotide data, little progress has been ...

We extract 11 genome-wide sets of breakpoint positions from databases on reciprocal translocations, inversions and deletions in neoplasms, reciprocal translocations and inversions in families carrying rearrangements and the human-mouse comparative map, and for each set of positions construct breakpoint distributions for the 44 autosomal arms. We identify and interpret four main types of distrib...

Chromosomal inversions are ubiquitous in nature and of great significance for understanding adaptation and speciation. Inversions were the first markers used to investigate the genetic structure of natural populations, leading to the concept of coadapted gene complexes and theories concerning founder effects and genetic drift in small populations. However, we still lack elements of a general th...