Cancer Metastasis Highlighting article number 2100684 by Janine T. Erler, Alejandro E. Mayorca-Guiliani and co-workers, this cover represents cancer cells extravasating out of a vessel into decellularized extracellular matrix (ECM) organ scaffold. Upon arriving in the capillary bed, adhere to ECM use it migrate organ. The authors' metastasis model system is based on bioreactor where scaffolds a...

In this study, granulated sludge synthesized in a sequence batch reactor (SBR) and then granulated sludge was transferred to continuous feeding and intermittent discharge (CFID) bioreactor. Two independent variables (air flow rate and hydraulic retention time (HRT)) were considered to optimize the process. Subsequently, long term performance (150 days) of the bioreactor was assessed by monitori...

Background Pathomechanisms of degenerative joint diseases such as osteoarthritis (OA) ultimately result in the breakdown cartilage tissue. To date, exact underlying mechanisms both cause and progression OA remain unclear. Therefore, developing complex long-lasting vitro components a human including cartilage, subchondral bone, synovial membrane tendons that simulate 3D architecture metabolic, h...

Different control strategies of bed temperature and moisture were investigated using various inlet air temperatures and air fluxes in both the ordinary packed bed bioreactor (without cooling water in the jacket) and the bioreactor with cooling water in jacket. The experiments were carried out within a 1-L solid-state packed bed bioreactor in which Aspergillus niger was cultivated on wheat bran....

As per definition, the bioreactor is the designed space where biological reactions take place. Hence, the bioreactor is essentially an engineering achievement and its design a challenge for bioengineers. The bioreactor should create a biosphere that as profoundly and adequately as possible provides the ideal environment for the biological reaction. The path for reaching, attaining, andmaintaini...

selected genotypes of sugar beet are often maintained by conventional propagation, but much faster rates of multiplication can be now obtained through micropropagation. on the other hand, plant micropropagation using bioreactors can decrease the cost of production and makes it an economical method. in this research, the possibility of using bioreactor and optimization of the tissue culture proc...