Decrease of arterial wall shear stress (WSS) is associated with higher probability of atherosclerotic plaque development in many disease conditions. End-stage renal diseases (ESRD) patients suffer from vascular disease frequently, but its nature differs from general population. This study was aimed at proving an association between common carotid wall shear stress and the presence of carotid bi...

High levels of fluid shear stress at the blood vessel wall directly stimulate von Willebrand factor (vWF)-mediated platelet adhesion and aggregation and thereby contribute to the pathogenesis of arterial thrombosis. We have found that a pathological level of arterial wall shear stress (90 dynes/cm2) induces platelet aggregation that is associated with the phosphorylation of pleckstrin, a M(r) 4...

During the analysis of reinforced concrete structures, the infill wall is usually simplified as a diagonal inclined strut to facilitate finite element modeling calculations. However, the actual seismic damage and single frame-filled wall pushover experimental results show that when the earthquake shear force is huge, the top of the infill wall and the beam–column connections are usually, thus t...

Recent shear experiments in well-entangled polymer solutions demonstrated that interfacial wall slip is the only source of shear rate loss and there is no evidence of shear banding in the micron scale gap. In this work, we experimentally elucidate how molecular parameters such as slip length, b, influence shear inhomogeneity of entangled polybutadiene (PBD) solutions during shear in a small gap...

Cost-effective, lightweight design alternatives for the thermal management of heat transfer equipment are required. In this study, porous plate and perforated-porous plates used nanoliquid convection control in a flexible-walled vented cavity system under uniform magnetic field effects. The finite element technique is employed with arbitrary Lagrangian–Eulerian (ALE) method. numerical study per...

In this work we propose a novel approach to model order reduction for incompressible fluid flows that focuses on the spatio-temporal description of the stresses on the surface of a body, i.e. of the wall shear stress and of the wall pressure. The spatial representation of these two variables is given by a compact set of “wall basis functions”, i.e. elementary basis functions defined on the wall...

Leukocyte adhesion through L-selectin to peripheral node addressin (PNAd, also known as MECA-79 antigen), an L-selectin ligand expressed on high endothelial venules, has been shown to require a minimum level of fluid shear stress to sustain rolling interactions (Finger, E.B., K.D. Puri, R. Alon, M.B. Lawrence, V.H. von Andrian, and T.A. Springer. 1996. Nature (Lond.). 379:266-269). Here, we sho...

INTRODUCTION AND OBJECTIVES Local factors may influence neointimal proliferation following conventional stent implantation. In this study, the relationship between wall shear stress and luminal loss after coronary stenting was assessed using a combination of angiography, intravascular ultrasound, and computational fluid dynamics. PATIENTS AND METHOD Seven patients with de novo right coronary ...

The effect of spatially varying shear on transport to the wall of a two-dimensional branch was examined, using oxygen as the test solute and the results of earlier fluid mechanical calculations to provide the shear profiles in a region characterizing the aortic bifurcation. The numerical technique employed allowed both blood-phase and mural resistances to solute uptake to be treated simultaneou...

In this present work, a cost optimization has been done for r/c structural system by genetic algorithm method. In the optimization problem the shear-wall dimensions has been considered as design variables and it has been aimed at searching the optimum shear-wall dimensions that minimize total material cost of shear-wall. The constraints of structural optimization problem are constructed accordi...