Melanoma is a deadly disease at late metastatic stage, and early diagnosis and accurate staging remain the key aspects for managing melanoma. The melanocortin 1 receptor (MC1 R) is overexpressed in primary and metastatic melanomas, and its endogenous ligand, the α-melanocyte-stimulating hormone (αMSH), has been extensively studied for the development of MC1 R-targeted molecular imaging and ther...

The gastroenteropancreatic (GEP) neuroendocrine tumors (NETs) are rare tumors and include all tumors arising from the gastrointestinal (GI) or pancreatic neuroendocrine cells. They can occur anywhere in the GI tract with the small intestine, pancreas and rectum being the common GI sites. Because of nonspecific symptoms they are difficult to diagnose and diagnosis is often delayed by years. Adva...

BackgroundThis review and meta-analysis examined published evidence of peptide receptor radionuclide therapy (PRRT) re-treatment efficacy safety in patients with advanced neuroendocrine tumors (NETs).MethodsEmbase, MEDLINE, MEDLINE In-Progress, Cochrane CENTRAL were searched (database inception–present) to identify PRRT adults NETs previously treated 177Lu- and/or 90Y-PRRT. Progression-free sur...