introduction: scorpion venom is a source of bioactive peptides, and some antimicrobial peptides (amps) have been found in the venom gland of scorpions. therefore, the discovery of new anti-infective agents is an essential need to overcome the problem of antibiotic resistance of clinical isolates. here, we describe three new cationic amps, including meuvap-6, meuap-18-1, and meupep34 from the ve...

background one of the main components involving in the pathogenesis and prognosis of sepsis and septic shock is natriuretic peptide. hemodynamic changes in sepsis or septic shock might explain increased plasma levels of these peptides circulations. objectives the present study aimed to assess the value of brain natriuretic peptide (bnp) in prediction of sepsis state and its related morbidity. w...

background: alzheimer’s disease (ad) is one of the most important neurodegenerative disorder. anti‑cyclic citrullinated peptide (anti‑ccp) may all be involved in the development of vascular disease such as ad. the aim of this study is detection of seropositivity for anti‑ccp antibody in ad patients. methods: in our study, 30 patients with ad and 29 healthy controls (age and‑sex matched) were re...

purpose : to investigate the effects of mtp-131 on trabeculum cells cultured under hydrostatic pressure methods : glaucomatous human trabecular meshwork (gtm3) cells were divided into three groups: the mtp-131 group, the hydrostatic group, and the normal group. the mtp-131 group was pretreated with 1 µm mtp-131, and the cells were then cultured under 80 mmhg pressure for 24 hours. the normal gr...

introduction: the aim of this study was to evaluate the effects of aerobic exercise on brain natriuretic peptide (bnp) and c-reactive protein (crp) levels in women with cardiovascular diseases. materials and methods: in this semi experimental study, thirty female patients with at least one coronary artery stenosis (more than70%) were chosen and divided into two groups of aerobic training (n=15)...

melanocortin- 4 receptor (mc4r) and agouti- related peptide (agrp) are involved in energy homeostasis in rats. according to mc4r and agrp effects on luteinizing hormone (lh) secretion, they may influence the estrous cycle of rats. therefore, the aim of this study was to investigate the expression of mc4r and agrp mrnas at different stages of estrous cycle in the rat’s hypothalamus. the estrous ...

introduction: ubiquicidin (ubi) 29-41 is a synthetic antimicrobial peptide that binds with the microbial cell membrane at the location of infection. this study was conducted to evaluate its probable efficacy as an infection-imaging agent with potential to differentiate bacterial infection from sterile inflammation in humans. methods: fifteen diabetic foot patients (10 males and 5 females) with...

background: ubi 29-41 (a derivative of antimicrobial peptide ubiquicidin) labelled with 99mtc is reported to discriminate between bacterial infections and sterile inflammatory processes. in this study, three lyophilized kit were performed, one of them based on the direct labelling with only sncl2 as reducing agent , and other two based on 6- hydrazinopyridine-3-carboxylic acid (hynic) and trici...

Background: Defensin peptide isolated from plants are often heterogeneous in length, sequence and structure, but they are mostly small, cationic and amphipathic. Plant defensins exhibit broad-spectrum antibacterial and antifungal activities against Gram-positive and Gram-negative bacteria, fungi and etc. Plant defensins also play an important role in innate immunity, such as he...