The novel coronavirus, SARS-CoV-2, broken out as the COVID-19 epidemic, is transported into cytoplasm by angiotensin-converting enzyme-2 (ACE2), a key protein of renin-angiotensin-system (RAS). ACE2 protective that reduces angiotensin (Ang) II, bioactive component RAS, converting it to its potent antagonist, Ang-(1-7) peptide, in order provide pathophysiological response stimuli. Although ACE-2...

Abstract Background Malnutrition is a common finding after major abdominal surgeries especially prolonged period of fasting in children. Enteral feeding the commonest support way postoperatively for stimulating gut hormones, modulating immunity, and maintaining barrier function intestinal mucosa. Our aim was to compare results outcome regarding tolerance, nutritional status, hospital stay follo...

Peptide-based strategies have received an enormous amount of attention because their specificity and applicability. Their tumor-targeting ability are applied to diagnosis treatment for cancer patients. In this review, we will summarize recent advancements future perspectives on peptide-based treatment. The literature search was conducted identify relevant articles It performed using PubMed in E...

introduction: influenza a virus causes unpredictable epidemics and pandemics by creating antigenic variations. with the appearance of each new strain, rapid emergency countermeasures are taken against this new strain. hence, designing an applicable and cross protective strategy to counter this virus is of great importance. to achieve this, choosing conserved antigenic regions in influenza virus...

Peptide-oligonucleotide conjugates (POCs) represent one of the increasingly successful albeit costly approaches to increasing cellular uptake, tissue delivery, bioavailability, and, thus, overall efficiency therapeutic nucleic acids, such as, antisense oligonucleotides and small interfering RNAs. This review puts subject chemical synthesis POCs into wider context problem acid drug cell-penetrat...

The most prominent problem in the current citrus industry worldwide is epidemic of Huanglongbing (HLB), also known as greening disease. Huang et al. identified a stable peptide, which has antimicrobial activities and induces systemic immune response against HLB, from Australian finger lime. This peptide effectively suppresses disease symptoms protects healthy trees this

Peptide mapping is a key method for studying the primary structure of proteins. With its sensitivity to slightest changes in covalent protein, this applicable both medicinal product identification at control stage and production process stability monitoring. The aim study was develop validate peptide-mapping procedure novel highly glycosylated recombinant C1 esterase inhibitor. Materials method...

Tumor-targeted therapies are playing growing roles in cancer research. The exploitation of these powerful therapeutic modalities largely depends on the discovery of tumor-targeting ligands. Phage display has proven a promising high throughput screening tool for the identification of novel specific peptides with high binding affinity to cancer cells. In the present study, we describe the use of ...

Background: Chlorotoxin is a 36-amino acid peptide found in the venom of the Leiurus quinquestriatus which blocks small-conductance chloride channels. Chlorotoxin binds preferentially to glioma cells that allow development of new methods for the treatment and diagnosis of several types of cancer. Thus chlorotoxin derivative was labeled with 131I for further investigation. Materials and...

The zinc metalloprotease, neprilysin (NEP), plays a role in the metabolism of cardiovascular, inflammatory and neuropeptides, including mitogenic peptides such as bombesin. In the cardiovascular system, NEP has a primary role in the inactivation of natriuretic peptides but also contributes to local metabolism of angiotensin, endothelins and bradykinin. Hence NEP is seen as a potential therapeut...