Prosopis africana (Guill and Perr) Taub fruit methanolic extract was tested for its antinociceptive properties. 4.2% w/w dry yield obtained after 48 hours of 80% methanol at room temperature during cold maceration. occasional shake every two hours. It had a golden brown color, sticky odorous, foamed as it dissolved in distilled water. In mice, the did not exhibit any acute hazardous effects stu...

The effect of vecuronium on intracranial pressure (ICP) was investigated in six cats with normal and increased ICP. Cats were anaesthetized with pentobarbitone 33 mg kg-1 i.p. and acepromazine 0.6 mg kg-1 i.p., the trachea was intubated, and the lungs ventilated with nitrous oxide in oxygen. Mean arterial pressure (MAP), heart rate (HR), twitch response and ICP were recorded continuously. After...

Male mongrel dogs were used. Methods of inducing acidosis and alkalosis described by Lew et al (5) were followed with modifications. Metabolic acidosis was induced by oral administration of ammonium chloride (5.3 g/day for five days) (n=10). Control animals (n=6) were given sodium chloride (5.85 g/day) in the same manner. Animals were used for the experiments on the sixth day. Metabolic alkalos...

The research work deals with the screening of ethanol and chloroform extracts of Pachyrrhizus erosus seeds for central nervous system (CNS) depressant activity. The Pachyrrhizus erosus seed is known to contain rotinoids, flavonoids and phenylfuranocoumarin derivatives as chemical components and is reported to have antifungal, antisecretory, insecticides, antibacterial and spasmolytic activity. ...

Arterial plasma renin activity in the rabbit was measured at the beginning and end of a brisk hemorrhage and 40 min later. Activity rose to a mean of two and one-half times the control value during the hemorrhage, and was five times greater than the control 40 min later. The rise in plasma renin activity was not due to anesthesia, as light pentobarbitone produced no change. Conscious rabbits, s...

OBJECTIVES The aim of present study was to evaluate some effects of Crinum zeylanicum (C. zeylanicum) on central nervous system. MATERIALS AND METHODS C. zeylanicum methanolic bulb extract (250-1000 mg/kg orally), 2 mg chlorpromazine and 4 mg diazepam /kg body weight intraperitoneally respectively were tested in mice using Irwin test, pentobarbitone-induced sleep test, spontaneous motor activ...

The effects of sodium thiopentone 19-757 mumol/litre, sodium pentobarbitone 25-806 mumol/litre, propanidid 74-1186 mumol/litre, Althesin 55-220 mumol/litre, diazepam 17.6-140 mumol/litre and ketamine 1.8-116.8 mumol/litre on the time-course of miniature end-plate currents of the excised mouse diaphragm were investigated. The currents were detected by means of extracellular electrodes and record...

Vettumaran Gutika produced moderate CNS depressant effect, prolonged pentobarbitone and diazepam induced sleep, produced initial depression followed by stimulation of SMA in mice. It did not effect SCR and CAR in rats, reserpine effects in mice and threshold of tail-flick response in rats. It failed to protect rats and mice aginst Electro, pentylenetetrazol and strychnine induced convulsions an...

Chloral hydrate, pentobarbitone and urethane were evaluated and compared for onset, duration and depth of anaesthesia, cardiovascular and respiratory effects, nociception and mortality in adult male rats. Chloral hydrate (300 and 400 mg/kg) severely depressed the cardiovascular and respiratory systems. Duration of anaesthesia was linearly related to dose, and anaesthetic depth and analgesia wer...

The study of toxicities which are caused by free radical inducing chemicals (e.g., carbon tetrachloride), helps to determine the mode of action of those important drugs which act by inhibiting free radicals. Evaluation of toxicities induced by carbon tetrachloride and phenobarbitone administration was carried out in seventy healthy male rabbits. Each animal received CCI4 0.25-0.5 mL/kg bod...