1. Cardiovascular and Thoracic Imaging Department, University Hospital, Sart Tilman B35, 4000 Liège, Belgium 2. Cardiovascular and Thoracic Surgery Department, University Hospital, Sart Tilman B35, 4000 Liège, Belgium 3. Royal Institute of Technology (KTH), Department of Solid Mechanics. Osquarsbacke 1, 100 44 Stockholm, Sweden 4. Nuclear Medicine Department, Centre Hospitalier Chrétien St Jose...

The aim of the current study was to investigate the antitumor potential of poly (D,L-lactic-co-glycolic acid) microspheres (PLGA MSs) containing polyethylene glycol (PEG)-conjugated (PEGylated) tumor necrosis factor-related apoptosis-inducing ligand (PEG-TRAIL). PEG-TRAIL PLGA MSs were prepared by using a water-in-oil-in-water double-emulsion method, and the apoptotic activities of supernatants...

Chronic hepatitis C (CHC) is one of the most common causes of liver diseases worldwide, affecting 3% of the world population and 3 to 4 million people acquire new infection annually. Despite the recent introduction of novel antiviral drugs for the treatment of CHC, these drugs are expensive and the access to them is not an option for many patients. Hence, the traditional therapy by pegylated in...

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The apparent solubilities of various proteins (14,000 to 670,000 daltons) were measured in the presence of polyethylene glycols (PEGs) of different sizes. All of the solubility curves, determined by measuring the protein concentration in the supernate of centrifuged mixtures, exhibited the characteristic linear dependence of log S (g/liter) on PEG concentration (%, w/v). For human albumin in PE...

A series of new, covalent polyethylene glycol (PEG)-streptokinase adducts were synthesized and characterized. PEGs with average molecular weights of 2,000, 4,000, and 5,000 were activated with carbonyldiimidazole and coupled to the protein under standardized reaction conditions. Steady-state kinetic analysis demonstrated comparable Km values for the activation of plasminogen by streptokinase, P...

The apparent solubilities of various proteins (14,000 to 670,000 daltons) were measured in the presence of polyethylene glycols (PEGS) of different sizes. All of the solubility curves, determined by measur ing the protein concentration in the supernate of centrifuged mixtures, exhibited the characteristic linear dependence of log S (g/liter) on PEG concentration (%, w/v). For human albumin in P...

The hypothesis tested was that tropical steers supplemented with the Desmanthus legume and lucerne, a widely characterized temperate of high nutritive value, would elicit similar responses in plasma metabolite profiles, productive performance, nitrogen retention, volatile fatty acids (VFA). tannin-binding compound, polyethylene glycol-4000 (PEG), added to diets (160 g/kg dry matter) objective f...

Mango peel is a good source of protease but remains an industrial waste. This study focuses on the optimization of polyethylene glycol (PEG)/dextran-based aqueous two-phase system (ATPS) to purify serine protease from mango peel. The activity of serine protease in different phase systems was studied and then the possible relationship between the purification variables, namely polyethylene glyco...