نتایج جستجو برای: pecam 1

تعداد نتایج: 2752638  

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2009
Suzanne J A Korporaal C Arnold Koekman Sandra Verhoef Dianne E van der Wal Martineke Bezemer Miranda Van Eck Jan-Willem N Akkerman

OBJECTIVE The sensitivity of platelets to aggregating agents increases when low-density lipoprotein (LDL) binds to apolipoprotein E receptor 2' (apoER2'), triggering activation of p38MAPK and formation of thromboxane A2. LDL signaling is terminated by PECAM-1 through recruitment and activation of the Ser/Thr protein phosphatase PP2A, but platelets remain unresponsive to LDL when PECAM-1 activat...

Journal: :Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1997
I A Hauser R Riess B Hausknecht H Thüringer R B Sterzel

BACKGROUND In vitro studies have demonstrated that inflammatory mediators such as the cytokines TNF alpha and IL-1 upregulate or induce de novo expression of cell adhesion molecules on endothelial and epithelial cells. In the present study the expression of the cell adhesion molecules ICAM-1, VCAM-1, E-selectin and PECAM-1 was investigated in renal biopsies from patients with primary renal dise...

2013
Jian Tu Zhiqiang Hu Zhongbin Chen

Radiosurgery for cerebral arteriovenous malformations (AVMs) is limited to 2-year latency. There is no early marker to monitor whether the lesion is responsive to radiosurgery. In this study, we examined endothelial gene expression and molecular changes in response to radiosurgery. Gene expression of E- and P-selectin, ICAM-1, PECAM-1, VCAM-1, tissue factor, and vWF in human cerebral microvascu...

Journal: :European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes 2004
D Nolte W M Kuebler W A Muller K-D Wolff K Messmer

BACKGROUND Molecular mechanisms regulating leukocyte sequestration into the tissue during endotoxemia and/or sepsis are still poorly understood. This in vivo study investigates the biological role of murine PECAM-1 and VCAM-1 for leukocyte sequestration into the lung, liver and striated skin muscle. METHODS Male BALB/c mice were injected intravenously with murine PECAM-1 IgG chimera or monocl...

Journal: :Journal of immunology 2001
J T Kaifi E Diaconu E Pearlman

Infiltration of granulocytes into the transparent mammalian cornea can result in loss of corneal clarity and severe visual impairment. Since the cornea is an avascular tissue, recruitment of granulocytes such as neutrophils and eosinophils into the corneal stroma is initiated from peripheral (limbal) vessels. To determine the role of vascular adhesion molecules in this process, expression of pl...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2012
Laura Fernández-Martín Beatriz Marcos-Ramiro Carolina L Bigarella Mariona Graupera Robert J Cain Natalia Reglero-Real Anaïs Jiménez Eva Cernuda-Morollón Isabel Correas Susan Cox Anne J Ridley Jaime Millán

OBJECTIVE Endothelial cells provide a barrier between the blood and tissues, which is reduced during inflammation to allow selective passage of molecules and cells. Adherens junctions (AJ) play a central role in regulating this barrier. We aim to investigate the role of a distinctive 3-dimensional reticular network of AJ found in the endothelium. METHODS AND RESULTS In endothelial AJ, vascula...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید