Although food allergy has emerged as a major health problem, the mechanisms that are decisive in the development of sensitization to dietary Ag remain largely unknown. CTLA-4 signaling negatively regulates immune activation, and may play a crucial role in preventing induction and/or progression of sensitization to food Ag. To elucidate the role of CTLA-4 signaling in responses to food allergens...

In 2010, a team of US researchers concluded that the more peanuts a pregnant woman ate during her pregnancy [4], the more likely her newborn was to be sensitive to peanuts. They published their results in 2010's "Maternal consumption of peanut during pregnancy [4] is associated with peanut sensitization in atopic infants". The work resulted from the collaboration of Scott Sicherer and Hugh Samp...

A collection of Practice Guidelines published in AFP is available at http:// www.aafp.org/afp/ practguide. In westernized countries, 1% to 3% of children have a peanut allergy, with almost 100,000 new cases each year in the United States and United Kingdom. This consensus communication focuses on new data that support introducing peanuts early in infants, and it aims to assist with decisions ab...

Introduction Non-specific lipid transfer proteins (LTPs) are panallergens present in plant foods and are recognized as maior allergens in patients allergic to Rosaceae family fruits from the Mediterranean area. On the contrary, seed storage proteins are the most important allergens in peanut allergy worldwide, although some authors from Southern Europe found Ara h 9 (peanut LTP) as the maior al...

Methods We present the case of a girl, who was diagnosed with peanut allergy at age 8 after she developed abdominal pain, urticaria and angioedema following a meal of cornflakes with peanut chips. No food challenge was performed at that time, and she was advised to avoid peanuts. Despite avoiding foods visibly containing peanut, she repeatedly experienced urticaria, burning of the tongue, nause...

Background: The eliciting dose (ED) for a peanut allergic reaction in 5% of the peanut allergic population, the ED05, is 1.5 mg of peanut protein. This ED05 was derived from oral food challenges (OFC) that use graded, incremental doses administered at fixed time intervals. Individual patients’ threshold doses were used to generate population dose-distribution curves using probability distributi...

OBJECTIVE To make recommendations based on a critical review of the evidence for the timing of the introduction of solid foods and its possible role in the development of food allergy. DATA SOURCES MEDLINE searches using the following search algorithm: [weaning AND infant AND allergy]/[food allergy AND sensitization]/[dietary prevention AND food allergy OR allergens]/[Jan 1980-Feb 2006]. ST...

Performance of commercially available component resolved microarray has not been widely evaluated in food allergy. Nut allergy is a prevalent and increasing food allergy in which component resolved diagnosis is crucial. In the context of a multicentric study on pollen and vegetable food allergy in Spain, we enrolled patients (n=100) who had suffered at least two episodes of immediate symptoms a...

Results We assessed 113 challenges (35 peanut, 28 egg, 12 tree nut, 11 milk, 27 other). There were 29 failures (22 objective, 7 subjective). Among objective challenge failures, 4/7 cashew (57%), 10/35 (29%) peanut, and 6/28 egg (21%) failed. There were no failed milk challenges. Most (79%) failed peanut/cashew challenges occurred at doses ≤1.0g while 50% of failed egg challenges were final dose...

Background We have previously estimated that the annual rate of accidental exposure (AE) to peanut in a Canadian cohort of 1411 children with peanut allergy, followed for 2227 patient-years, was 11.9% [1]. The cohort has increased to 1825 children, with 4134 patient-years of follow-up, and we determined the incidence of AE in this expanded cohort and described the severity, management, and loca...