OBJECTIVE To evaluate lung function and respiratory muscle strength in the postoperative period and investigate the effect of inspiratory muscle training on measures of respiratory muscle performance in patients undergoing coronary artery bypass grafting. METHODS A randomized study with 47 patients undergoing coronary artery bypass grafting with cardiopulmonary bypass. They were divided into ...

BACKGROUND Pressure support ventilation from a bilevel device is a standard technique for non-invasive home ventilation. A bench study was designed to compare the performance and patient-ventilator synchronization of 7 bilevel ventilators, in the presence of system leaks. MATERIAL/METHODS Ventilators were connected to a Hans Rudolph Series 1101 lung simulator (compliance, 50 mL/cmH2O; expirat...

We wanted to evaluate whether lung deposition of budesonide and terbutaline sulphate differs, and to determine lung deposition of budesonide inhaled at different peak inspiratory flows, through Turbuhaler. Lung deposition of budesonide, a lipophilic substance, and of terbutaline sulphate, a hydrophilic substance, was therefore compared, after administration via an inspiratory flow-driven, multi...

OBJECTIVE To assess the efficacy and safety of fluticasone propionate administered using OptiNose's novel delivery device (Opt-FP) in subjects with bilateral mild-to-moderate nasal polyposis. METHODS A prospective, multicentre, randomized, double-blind, placebo-controlled, parallel group study was conducted in adult subjects (n = 109) with mild-to-moderate bilateral nasal polyposis. Subjects ...

It is claimed that suddenly squeezing a newborn baby's trunk with a pressure of 3-4 kPa produces a flow volume curve that can be used to measure the function of the small airways. If the squeeze is applied during expiration rather than at the end of inspiration, however, anomalous results may be obtained. One possible explanation is that the babies are limiting expiratory flow by making inspira...

IMPORTANCE External nasal valve dysfunction (EVD) is a common cause of nasal obstruction. OBJECTIVE To evaluate costal cartilage lateral crural strut grafts vs cephalic crural turn-in to support the weak lateral crus in patients with EVD. DESIGN, SETTING, AND PARTICIPANTS In this prospective cohort study, patients with clinically diagnosed EVD were assessed at the Tertiary Rhinologic Center...

INTRODUCTION A combination of antihistamines and oral corticosteroids is often used to treat acute symptoms of allergic rhinitis. OBJECTIVE To evaluate safety and efficacy of desloratadine plus prednisolone in the treatment of acute symptoms of children (2-12 years) with allergic rhinitis, and to compare it to dexchlorpheniramine plus betamethasone. METHODS Children with moderate/severe per...

INTRODUCTION Nasal obstruction is a common symptom in childhood, related to rhinitis and pharyngeal tonsil hypertrophy. In the presence of nasal obstruction, nasal patency may be reduced, and nasal breathing is replaced by mouth breathing. Orofacial and otorhinolaryngologic changes are related to this breathing mode. Objective evaluation of upper airways may be obtained through nasal patency me...

BACKGROUND : Allergic rhinitis (AR) affects up to 36% of the population in the Middle East Gulf States. The second-generation nonsedating antihistamine desloratadine has demonstrated safety and efficacy in the treatment of AR; however, few studies have evaluated this agent in Arab and Asian populations in the Middle East. METHODS : This open-label study enrolled subjects ≥12 years with modera...

REVIEW QUESTION/OBJECTIVE The objective is to identify the effect of peak inspiratory pressure on the development of postoperative pulmonary complications.More specifically, the objective is to identify the effect of maintaining intraoperative peak inspiratory pressure less than or equal to 30 cmH2O compared with peak inspiratory pressure greater than 30 cmH2O on the incidence of postoperative ...