نتایج جستجو برای: pdz domain

تعداد نتایج: 406848  

Journal: :The Journal of biological chemistry 1999
I Yao Y Hata N Ide K Hirao M Deguchi H Nishioka A Mizoguchi Y Takai

Postsynaptic density (PSD)-95/Synapse-associated protein (SAP) 90 and synaptic scaffolding molecule (S-SCAM) are neuronal membrane-associated guanylate kinases. Because PSD-95/SAP90 and S-SCAM function as synaptic scaffolding proteins, identification of ligands for these proteins is important to elucidate the structure of synaptic junctions. Here, we report a novel protein interacting with the ...

2016
Hulikal Shivashankara Santosh Kumar Vadlapudi Kumar

The inventory of proteins used in different kingdoms appears surprisingly similar in all sequenced eukaryotic genome. Protein domains represent the basic evolutionary units that form proteins. Domain duplication and shuffling by recombination are probably the most important forces driving protein evolution and hence the complexity of the proteome. While the duplication of whole genes as well as...

Journal: :Proteins: Structure, Function, and Bioinformatics 2006

2013
Efstathia Kitsou

Morphogenesis is the process which will define the final form of an organism by a series of complex cellular events such as cell division, shape changes and migration, events that require the coordinated modification of the cytoskeleton. The cytoskeleton is mainly regulated by the Rho family of small GTPases. The Guanine Nucleotide Exchange Factor, DRhoGEF2, is an activator of Rho 1 and it is e...

Journal: :Journal of the American Chemical Society 2013
Dustin S Whitney Francis C Peterson Evgenii L Kovrigin Brian F Volkman

Proteins exist in a delicate balance between the native and unfolded states, where thermodynamic stability may be sacrificed to attain the flexibility required for efficient catalysis, binding, or allosteric control. Partition-defective 6 (Par-6) regulates the Par polarity complex by transmitting a GTPase signal through the Cdc42/Rac interaction binding PSD-95/Dlg/ZO-1 (CRIB-PDZ) module that al...

2016
Artur Gieldon Dorota Zurawa-Janicka Miroslaw Jarzab Tomasz Wenta Przemyslaw Golik Grzegorz Dubin Barbara Lipinska Jerzy Ciarkowski

HtrA2(Omi) protease controls protein quality in mitochondria and plays a major role in apoptosis. Its HtrA2S306A mutant (with the catalytic serine routinely disabled for an X-ray study to avoid self-degradation) is a homotrimer whose subunits contain the serine protease domain (PD) and the regulatory PDZ domain. In the inactive state, a tight interdomain interface limits penetration of both PDZ...

Journal: :Journal of Molecular Modeling 2010

Journal: :International journal of molecular medicine 2011
Yingjie Mao Xu Huang Juan Zhao Zhiyuan Gu

The EphB4 receptor and ephrin B2 ligand were recently reported to influence the coupling between osteoclasts and osteoblasts in bone biology, but their downstream signaling pathways remain unclear. This study focuses on the preliminary identification of downstream PDZ-domain proteins involved in EphB4/ephrin B2 reverse signaling in osteoclasts. Similarly to primary osteoclast precursors isolate...

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