Phosphodiesterase-5 (PDE-5) inhibitors induces vasodilation in several organs by blocking cyclic GMP (guanosine monophosphate) degradation. However, the existence of alternative mechanism of action in case of an impaired nitric oxide (NO) system remains controversial. Previous studies suggested that decreased NO bioavailability may result in the downregulation of klotho expression, but the rela...

Asthma is a complex, multifactorial disease that is underpinned by airway inflammation. A variety of cytotoxic substances are released into the airway from infiltrating inflammatory cells, especially the eosinophil. These cytotoxic substances, including reactive oxygen metabolites, produce damage to the airway epithelium, a histologic feature of chronic asthma. Damage to the airway epithelium, ...

Analyses were done on a human type-IV cyclic AMP (cAMP) phosphodiesterase (hPDE-IVA-h6.1) expressed in an engineered strain of Saccharomyces cerevisiae. This strain (YMS6) expressed soluble PDE activity, together with an insoluble activity which was not released by re-homogenization, treatment with high-ionic-strength solutions or with the detergent Triton X-100. Pellet and soluble PDE activiti...

BACKGROUND Aging and insulin resistance have been related to reduced mitochondrial function and oxidative stress. Muscular phosphodiesters (PDE) are comprised of metabolites of phospholipid breakdown and may reflect membrane damage. We aimed to test the hypothesis that myocellular PDE are increased in patients with type 2 diabetes (T2D) and correlate inversely with mitochondrial ATP turnover. ...

Results of exact controllability will be reported for a semilinear thermoelastic system, with control placed in either the mechanical or thermal equation. The controlled partial differential equation (PDE) model will be considered in two cases: (i) rotational forces are present in the PDE, in which case, the underlying dynamics evince hyperbolic behavior; (ii) the rotational inertia parameter i...

In this paper we demonstrate the use of an anisotropic PDE to improve the behavior of first and second derivatives of a distance function. We begin by deriving a property of these derivatives and showing a M ~ U I ~ relationship between this property and the oati-geometric heatflow. We then conshuct a PDE that combines a known f i rs tader PDE with the anti-geometric flow and then demonstrate i...

polysaccharidase activity of duodenal digesta [1]. In theory, increased levels of PDE in the intestine of ruminants could affect digestibility and nutrient absorption. To test this possibility, an incomplete Latin square experiment with four heifers (469±6.Okg) and three treatments was conducted. Control (C) no enzyme addition; PDE-treated feed (EF) 48.Og PDE head&dquo; day’’ (1:1 mixture of a ...

Abstract We discuss practical methods for computing the space of solutions to an arbitrary homogeneous linear system partial differential equations with constant coefficients. These rest on Fundamental Principle Ehrenpreis–Palamodov from 1960s. develop this further using recent advances in computational commutative algebra.