Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the elderly. Wet AMD includes typical choroidal neovascularization (CNV) and polypoidal choroidal vasculopathy (PCV). The etiology and pathogenesis of CNV and PCV are not well understood. Genome-wide association studies have linked a multifunctional serine protease, HTRA1, to AMD. However, the precise role ...

PURPOSE The goal of the present research was to study post-treatment changes in polypoidal choroidal vasculopathy (PCV) shown by optical coherence tomography (OCT). METHODS The study included 12 patients with naive PCV. Photodynamic therapy and 3 consecutive intravitreal bevacizumab injections at 6-week intervals were given. Best corrected visual acuity, subretinal fluid (SRF), pigment epithe...

The authors administered procarbazine, 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU, lomustine), and vincristine (PCV) to 86 patients with recurrent glioblastoma. There were three partial responses, but no complete responses. Median progression-free survival was 17.1 weeks and progression-free survival at 6 months was 38.4%. World Health Organization grade III/IV hematologic toxicity was ...

BackgroundInvasive pneumococcal disease (IPD) is the leading cause of infectious death worldwide. This study aimed to describe epidemiology IPD and impact conjugate vaccine-10 (PCV-10) over a 10-year period in Bogotá, Colombia.MethodsThis was laboratory-based surveillance Streptococcus pneumoniae isolated from patients with 82 hospitals 10 years Colombia. Data were compared between two periods:...

Intra-abdominal hypertension (IAH) may co-occur with the acute respiratory distress syndrome (ARDS), with significant impact on morbidity and mortality. Lung-protective controlled mechanical ventilation with low tidal volume and positive end-expiratory pressure (PEEP) has been recommended in ARDS. However, mechanical ventilation with spontaneous breathing activity may be beneficial to lung func...

INTRODUCTION The localized BMP signaling that initiates the development of the posterior cross vein (PCV) from the epithelia of the Drosophila melanogaster pupal wing depends in large part on the BMPs Decapentaplegic (Dpp) and Glass bottom boat (Gbb), which are secreted from the earlier arising longitudinal veins (LVs) (Conley et al., 2000; Ray and Wharton, 2001; Ralston and Blair, 2005). Altho...

OBJECTIVE To determine if acute pain response after administration of the diphtheria, polio, and tetanus toxoids and acellular pertussis and Haemophilus influenzae type b (DPTaP-Hib) vaccine and the pneumococcal conjugate vaccine (PCV) is affected by the order in which they are given. DESIGN Single-center, double-blind, randomized clinical trial. SETTING Outpatient pediatric clinic in Toron...

Immune-mediated hemolytic anemia (IMHA) is characterized by the destruction of erythrocytes or sometimes bone marrow erythroid precursors mediated by immunoglobulins (IgG, IgM), with or without complement (C 3). The main objectives of this study were to assess the laboratory test results of IMHA and to investigate its possible underlying causes in cats referring to the Veterinary Teaching Hosp...

This paper describes a parallel cross-validation (PCV) procedure, for testing the predictive ability of multi-layer feed-forward (MLF) neural networks models, trained by the generalized delta learning rule. The PCV program has been parallelized to operate in a local area computer network. Development and execution of the parallel application was aided by the HYDRA programming environment, which...

PURPOSE To investigate the association of genetic and environmental factors, and their interactions in Korean patients with exudative age-related macular degeneration (AMD). METHODS A total of 314 robustly characterized exudative AMD patients, including 111 PCV (polypoidal choroidal vasculopathy) and 154 typical choroidal neovascularization (CNV), and 395 control subjects without any evidence...