Pharmacological research on the medicinal properties of phytochemicals has become mandatory to establish the claimed medicinal properties of herbs. Paracetamol (PCM) is a commonly used analgesic and antipyretic agent which, at high doses, causes liver and kidney necrosis in man and animals. The aim of this study was to investigate nephroprotective activity of hydro-alcoholic extract of Benincas...

Paracoccidioides brasiliensis and P. lutzii are fungi that cause paracoccidioidomycosis (PCM), the most prevalent systemic mycosis in South America. For serological diagnosis, although 43-kDa glycoprotein (gp43) is regarded as highly specific for PCM, the occurrence of false negative reactions in sera from patients infected with P. lutzii suggests that preparation with only one antigen is not r...

We have shown that Caenorhabditis elegans lacking the PCM-1 protein repair l-isoaspartyl methyltransferase are more sensitive to oxidative stress than wild-type nematodes. Exposure to the redox-cycling quinone juglone upon exit from dauer diapause results in defective egg-laying (Egl phenotype) in the pcm-1 mutants only. Treatment with paraquat, a redox-cycling dipyridyl, causes a more severe d...

Phase change materials (PCM) in the construction industry became attractive because of several interesting attributes, such as thermo-physical parameters, open air atmospheric condition usage, cost and the duty structure requirement. Thermal performance optimization of PCMs in terms of proficient storage of a large amount of heat or cold in a finite volume remains a challenging task. Implementa...

INTRODUCTION Paracoccidioidomycosis (PCM) is a systemic infection caused by the fungus Paracoccidioides brasiliensis. PCM is considered one of the most important systemic mycoses in Latin America. METHODS This is a clinical, epidemiological, retrospective, quantitative study of PCM cases in patients attending the National Health Service in the State of Rondônia in 1997-2012. The examined vari...

Centrosomes comprise a pair of centrioles surrounded by a matrix of pericentriolar material (PCM). In vertebrate cells, Pericentrin plays an important part in mitotic PCM assembly, but the Drosophila Pericentrin-like protein (PLP) appears to have a more minor role in mitotic fly cells. Here we investigate the function of PLP during the rapid mitotic cycles of the earlyDrosophila embryo. Unexpec...

Present study was aimed to investigate in vitro antioxidant and hepatoprotective activities of the ethanolic extracts of Astragalus subrobustus (A. subrobustus) and Astragalus woronowii (A. woronowii) on PCM induced liver damage in rats. The antioxidant activities of both extracts were assayed and their activities were compared to standard antioxidants, ascorbic acid and pyrogallol. Liver injur...

Primary cilia are cell surface sensory organelles, whose dysfunction underlies various human genetic diseases collectively termed ciliopathies. A new study in The EMBO Journal by Villumsen et al now reveals how stress–response pathways converge to stimulate ciliogenesis by modulating protein composition of centriolar satellites. Better understanding of these mechanisms should bring us closer to...

The performance of phase change material (PCM) integrated building envelope in terms of peak load reduction, peak load time delay and thermal demand improvement was investigated for a prototype detached single family house in a hot climate location. Five market available PCM layers, which can be easily inserted into traditional wall construction, were selected and coupled into different walls a...

In this paper, we study the performance of the PCM scheme with linear quantization rule for quantizing finite unit-norm tight frame expansions for R and derive the PCM quantization error without the White Noise Hypothesis. We prove that for the class of unit norm tight frames derived from uniform frame paths the quantization error has an upper bound of O(δ) regardless of the frame redundancy. T...