BACKGROUND Primary congenital glaucoma (PCG), occurs due to the developmental defects in the trabecular meshwork and anterior chamber angle in children. PCG exhibits genetic heterogeneity and the CYP1B1 gene has been widely implicated worldwide. Despite the diverse mutation spectra, the clinical implications of these mutations are yet unclear. The present study attempted to delineate the clinic...

Let T be an edge weighted tree, let dT (u, v) be the sum of the weights of the edges on the path from u to v in T , and let dmin and dmax be two non-negative real numbers such that dmin ≤ dmax. Then a pairwise compatibility graph of T for dmin and dmax is a graph G = (V, E), where each vertex u ∈ V corresponds to a leaf u of T and there is an edge (u, v) ∈ E if and only if dmin ≤ dT (u, v) ≤ dm...

PURPOSE To investigate variations in sex ratio among Iranian primary congenital glaucoma (PCG) patients with and without mutations in the CYP1B1 gene and to evaluate possible clinical variations associated with sex in these two groups. METHODS Phenotypical data on 104 unrelated Iranian PCG patients who had previously been screened for CYP1B1 mutations were analyzed. Emphasis was placed on ana...

Plasma cell infiltrates in the thyroid are rare. They may represent several processes, such as localized plasmacytoma, multiple myeloma, or plasma cell granuloma (PCG). It may be difficult to distinguish these disorders on the basis of morphologic features in sections stained with hematoxylin-eosin. All may be composed of mature plasma cells, without admixed macrophages or lymphocytes, that inf...

BACKGROUND Polycomb-group (PcG) and trithorax-group (trxG) proteins regulate histone methylation to establish repressive and active chromatin configurations at target loci, respectively. These chromatin configurations are passed on from mother to daughter cells, thereby causing heritable changes in gene expression. The activities of PcG and trxG proteins are regulated by a special class of prot...

To comply with recent international trends and initiatives, and in order to help achieve sustainable development, Korea has established a greenhouse gas (GHG) emission reduction target of 37% (851 million tons) of the business as usual (BAU) rate by 2030. Regarding environmentally-oriented standards such as the IGCC (International Green Construction Code), there are also rising demands for the ...

Heart murmurs have been found to be a life threatening condition for the newborns who are born with cardiac abnormalities. The first sign of pathological changes of heart valves appear in phonocardiogram (PCG) which contains very useful information about cardiovascular system. It is a challenging venture to distinguish pathological murmurs from innocent ones. In this paper, we have developed a ...

Polycomb group (PcG)-mediated repression of C. elegans Hox genes has not been demonstrated, and genes homologous to components of one of the PcG complexes (PRC1) have not been identified in the C. elegans genome. We find that a mechanism of general Hox gene repression exists in C. elegans, carried out in part by SOP-2, a protein related to, but not orthologous with, any PcG protein. sop-2 mutat...

The development of procedural content generation (PCG) methods for video games is an established area of research. There are many approaches to the problem that utilise a variety of techniques from different fields of computer science. The use of Answer Set Programming (ASP) for PCG in video games is relatively new, however recent research has demonstrated valuable aspects of ASP in the generat...

The polycomb group (PcG) proteins are a large and diverse family that epigenetically repress the transcription of key developmental genes. They form three broad groups of polycomb repressive complexes (PRCs) known as PRC1, PRC2 and Polycomb Repressive DeUBiquitinase, each of which modifies and/or remodels chromatin by distinct mechanisms that are tuned by having variable compositions of core an...