The effects of SK-896, a new human motilin analogue ([Leu13]motilin-Hse), on digestive tract motility in postoperative ileus were evaluated in a dog model of ileus after laparotomy. SK-896 was intravenously administered at 0.17, 0.33 and 0.67 microg/kg starting soon after operation and then at 6-h intervals, for a total of 9 times. SK-896 progressively, dose-dependently and significantly increa...

Although several recent studies employing various truncated fragments of streptokinase (SK) have demonstrated that the high-affinity interactions of this protein with human plasminogen (HPG) to form activator complex (SK-HPG) are located in the central region of SK, the exact location and nature of such HPG interacting site(s) is still unclear. In order to locate the "core" HPG binding ability ...

1. SK channels are small-conductance calcium-activated potassium channels that are widely expressed in neurons. The traditional view of the functional role of SK channels is in mediating one component of the after-hyperpolarization that follows action potentials. Calcium influx via voltage-gated calcium channels active during action potentials opens SK channels and the resultant hyperpolarizati...

If k is a positive integer, let Sk(N) denote the space of cusp forms of weight k on Γ1(N), and let S k (N) denote the subspace of Sk(N) spanned by those forms having complex multiplication (see [Ri]). For a non-negative integer k and any positive integer N ≡ 0 (mod 4), let Mk+ 2 (N) (resp. Sk+ 2 (N)) denote the space of modular forms (resp. cusp forms) of half-integral weight k + 12 on Γ1(N). S...

Let G = (V,A) be a directed graph without parallel arcs, and let S ⊆ V be a set of vertices. Let the sequence S = S0 ⊆ S1 ⊆ S2 ⊆ · · · be defined as follows: S1 is obtained from S0 by adding all out-neighbors of vertices in S0. For k > 2, Sk is obtained from Sk−1 by adding all vertices w such that for some vertex v ∈ Sk−1, w is the unique out-neighbor of v in V \ Sk−1. We set M(S) = S0 ∪S1 ∪ · ...

Oral administration of β-carotene (BC) was found to exert opposite effects on plasma levels of vascular endothelial growth factor (VEGF) in two animal models. One study in nude mice injected via tail vein with hepatocarcinoma SK-Hep-1 cells showed that BC decreases the plasma VEGF level, whereas the other study in nude mice injected subcutaneously with prostate tumor PC-3 cells showed that BC i...

Metastatic melanoma is an aggressive cancer with very low response rate against conventional chemotherapeutic agents such as dacarbazine (DTIC). Inhibitor of Rb–Raf-1 interaction RRD-251 was tested against the melanoma cell lines SK-MEL-28, SK-MEL-5, and SK-MEL-2. RRD-251 was found to be a potent inhibitor of melanoma cell proliferation, irrespective of V600E B-Raf mutation status of the cell l...

We have conducted a new search for the diffuse supernova neutrino background (DSNB) flux at Super-Kamiokande (SK), with 22.5×2970?kton·day exposure from its fourth operational phase IV. With analysis we improve on existing reduction techniques and systematic uncertainties take advantage of an improved neutron tagging algorithm to lower energy threshold compared previous phases SK. This allows s...

This paper studies the elementary symmetric polynomials Sk(x) for x ∈ Rn. We show that if |Sk(x)|, |Sk+1(x)| are small for some k > 0 then |S`(x)| is also small for all ` > k. We use this to prove probability tail bounds for the symmetric polynomials when the inputs are only t-wise independent, which may be useful in the context of derandomization. We also provide examples of t-wise independent...

Let G be an infinite connected graph with vertex set V. {Sn:n∈N0} the simple random walk on and let {ξ(v):v∈V} a collection of i.i.d. variables which are independent walk. Define in scenery as Tn= ∑k=0nξ(Sk), normalization Vn=(∑k=0nξ2(Sk))1∕2 Ln,2=(∑v∈Vln2(v))1∕2. For G=Zd G=Td, d-ary tree, we provide large deviations results for self-normalized process Tnn∕(L n,2Vn) under only finite moment as...