Background : Many studies have focused on oxidative stress induced damage and hence, the protective effects conferred by antioxidants. An example is neurodegenerative diseases which is thought to occur due to neuronal loss associated with oxidative stress. However, some antioxidants such as vitamin E have been shown to also exert pro-oxidative effects at high concentration.   Objective : In t...

Heavy metal pollution in mine wastelands is quite severe. Iris sibirica L., an emergent wetland plant, characterized by ability to survive under high stress of heavy metals. This study aimed explore the phytoremediation nickel (Ni), cobalt (Co), and lead (Pb) L. hydroponic conditions. A series tests were conducted at different conditions evaluate phytoextraction tolerance The concentrations Ni,...

Memory and mood deficits are the enduring brain-related symptoms in Gulf War illness (GWI). Both animal model and epidemiological investigations have indicated that these impairments in a majority of GW veterans are linked to exposures to chemicals such as pyridostigmine bromide (PB, an antinerve gas drug), permethrin (PM, an insecticide) and DEET (a mosquito repellant) encountered during the P...

Yeast Ssd1 is an RNA-binding protein that shuttles between the nucleus and cytoplasm. Ssd1 interacts with its target mRNAs initially during transcription by binding through its N-terminal prion-like domain (PLD) to the C-terminal domain of RNA polymerase II. Ssd1 subsequently targets mRNAs acquired in the nucleus either to daughter cells for translation or to stress granules (SGs) and P-bodies ...

We used a serum-free, highly defined primary hepatocyte culture model to investigate the mechanisms whereby dexamethasone (Dex) and extracellular matrix (ECM) coordinate cell differentiation and transcriptional responsiveness to the inducer, phenobarbital (PB). Low nanomolar levels of Dex and dilute concentrations of ECM overlay were essential in the maintenance of normal hepatocyte physiology,...

Nesprins are a multi-isomeric family of spectrin-repeat (SR) proteins, predominantly known as nuclear envelope scaffolds. However, isoforms that function beyond the nuclear envelope remain poorly examined. Here, we characterize p50(Nesp1), a 50-kD isoform that localizes to processing bodies (PBs), where it acts as a microtubule-associated protein capable of linking mRNP complexes to microtubule...

Species-specific changes in expression of phenylalanine ammonia-lyase (PAL) and lignin content were detected in roots of soybean (Glycine max L.) and lupine (Lupinus luteus L.) seedlings treated with different concentrations of cadmium (Cd(2+), 0-25 mg/l) or lead (Pb(2+), 0-350 mg/l). The stimulatory effect of both metals was observed in mRNA coding for PAL in soybean. In the case of lupine, ch...

background: the main threats to human health from heavy metals are associated with exposure to plumb (pb), cadmium, mercury, and arsenic. some hazards that threat human health are the results of environmental factors and the relevant pollutions. some important categories of diseases including (cancers) have considerable differences in various places, as observed in their spatial prevalence and ...

In a recently developed model of ion beam induced plastic deformation of amorphous solids, ion tracks are described as cylindrical thermoelastic inclusions formed upon local heating and shear stress relaxation along the ion trajectories. According to this model, track formation can be influenced or even suppressed by an applied stress. This model prediction is tested by studying the influence o...