The Pax gene family encodes a group of transcription factors whose evolution has accompanied the major morphological and functional innovations of vertebrate species. The evolutionary conservation throughout diverse lineages of metazoan and the functional importance in development rendered Pax family an ideal system to address the relationship inside Chordata phylum. In the present study, we se...

TTF-1 and PAX-8 are tissue-specific transcription factors expressed in the thyroid follicular cells, contributing to the maintenance of the differ entiated phenotype. In fact, it has been demonstrated that TTF-1 and PAX-S are able to activate transcription from thyroglobulin and thyroperoxidase (TPO) promoters, the transcriptional activity of which is in vivo restricted only to the thyroid foll...

TTF-1 and PAX-8 are tissue-specific transcription factors expressed in the thyroid follicular cells, contributing to the maintenance of the differentiated phenotype. In fact, it has been demonstrated that TTF-1 and PAX-8 are able to activate transcription from thyroglobulin and thyroperoxidase (TPO) promoters, the transcriptional activity of which is in vivo restricted only to the thyroid folli...

We describe here the isolation of chicken PAX6 and PAX7 as members of the PAX gene family expressed in late stages of chick nervous system development. By generating monoclonal antibodies against these PAX molecules, we analyzed their protein distributions in the CNS, neural crest cells and muscle precursor cells. Our detailed description of protein distributions revealed several new features o...

Apache Cassandra has emerged as one of the most widely adopted NoSQL databases. However, there is still a limited understanding on how to optimally operate Cassandra in the cloud using autoscaling methods, by which resources can be scaled up or down to reduce operational costs and meet servicelevel objectives (SLOs). To address this limitation, we present PAX, a partition-aware elastic resource...

This paper presents the results of an investigation that aimed to evaluate the efficiency of various inorganic coagulants and organic polymers to combat filamentous foaming and bulking problems, caused by the proliferation of M. parvicella and/or Gordona amarae. The duration of the investigation covered 14 months. During this period foam samples were taken from the aeration basins of two full-s...

Diagnosing metastatic renal cell carcinoma (RCC) by fine-needle aspiration (FNA) can be challenging. Existing antibodies supporting a diagnosis of RCC, including CD10 and RCC-Ma, have problems with specificity and interpretation. In this report, we evaluate the use of two newer immunostains, PAX-2 and gamma-H2AX, which to our knowledge have not been studied in FNA material, in the diagnosis of ...

Pax 6, a member of the paired box (Pax) family, has been implicated in oncogenesis. However, its therapeutic potential has been never examined in breast cancer. To explore the role of Pax6 in breast cancer development, a lentivirus based short hairpin RNA (shRNA) delivery system was used to knockdown Pax6 expression in estrogen receptor (ER)-positive (MCF-7) and ER-negative (MDA-MB-231) breast ...

Tennenhouse [1] coined the term proactive computing where humans get out of the interaction loop and may be serviced specifically according to their needs and current situation. In this paper we propose a framework for proactive guidance which aims to overcome limitations of today’s printed instructions. By attaching computing devices and multiple sensors onto different parts of the assembly th...

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