CHEST, VOL. 61, NO. 5, MAY 1972 ulcerations of the larynx. Recently, Caillard et al described a 34-year-old man who, after three years of chemotherapy for chronic Iymphocytic leukemia, developed a subglottic lymphomatous infiltrate. The tumor rapidly shrank in response to local radiotherapy. Localized lymphomas at this site are a!so rare. In 5,319 consecutive patients with malignant lymphoma se...

BACKGROUND In spite of potent first-line therapies for chronic lymphocytic leukemia, treatment remains palliative and all patients frequently relapse. Treatment options for these patients are more limited. BL22 is a recombinant protein composed of the variable region of a monoclonal antibody that binds to CD22 and of PE38, a truncated Pseudomonas exotoxin. BL22 is a very potent drug already use...

homogeneously staining regions (hsr) or double minute chromosomes (dmin) are autonomously replicating extra-chromosomal elements that are frequently associated with gene amplifi cation in a variety of cancers. the diagnosis of leukemia patients was based on characterization of the leukemic cells obtained from bone marrow cytogenetics. this study report two cases, one with acute myeloblastic leu...

The Leukemia & Lymphoma Society develops and distributes both detailed and easy-to-read booklets intended to help patients and caregivers communicate with healthcare providers about their treatment and support needs. The easy-to-read booklets initially were developed for newly diagnosed patients; however, the society has learned that all patients with cancer are likely to benefit from the infor...

The sialic acid content of erythrocytes from healthy individuals of different blood types and of patients with known hematological disorders has been determined. The sialic acid was completely released enzymatically with sialidase and quantitated by the thiobarbituric acid method. The sialic acid content of erythrocytes was constant irrespective of ABO blood type, or anticoagulant used; viz, 0....

introduction: lymphomas as a group rank seventh as the most leading cause of death in cancers. stomach is the most common extra nodal site of primary lymphomas. on the other hand, new information demonstrates that malt lymphoma responds to helicobacter antibiotic therapy. we therefore decided to determine the frequency of distribution of helicobacter pylori infection in primary gastric lymphoma...

conclusions this study showed that some lifestyle factors, particularly exposure to radiation, chemicals, pesticides, and contact with pets or livestock, can play an important role in etiology of leukemia. results exposure to radiation (p = 0.0001), chemicals (p = 0.02), pesticides (p = 0.01), and contact with pets or livestock (p = 0.0001) were associated with the risk of leukemia, but a histo...

The malignant lymphomas include at least 30 entities that are distinct with respect to histology, immunology, genetics, clinical features, and outcome following therapy. The clinical behavior of these diseases ranges from indolent but generally incurable to aggressive and frequently fatal yet potentially curable with appropriate chemotherapy or chemotherapy-antibody regimens. Over the past 50 y...

Parvovirus B19 has a marked tropism for erythroid progenitor cells. This may lead to chronic anemia in predisposed individuals. The purpose of the study was to investigate the frequency of parvovirus B19 infections in patients with diagnosis of haematological disorders. In order to determine the diagnostic use of different markers of parvovirus B19 infection, serum specimens obtained from 79 pa...