Numerous reports over the years have described neuroinflammatory events and vascular changes in neurodegenerative diseases such as Alzheimers disease (AD) and Dementia with Lewy bodies (DLB). Interestingly, recent reports from other research areas suggest that inflammatory and vascular processes are influenced by gender. These findings are intriguing from the perspective that women show a highe...

Vitamins are a heterogeneous group of organic compounds that help ensure the human bodys wellbeing and function. This paper introduces importance all vitamins, both water-soluble fat-soluble, as well problems deriving from their deficiency. Additionally, vitamin supplements part treating deficiency, possible harmful effects on body areshowcased. The main focus is B complex, B12 specifically. be...

The increase in Alzheimers disease is due to the aging of the population and is the first cause of neurodegenerative disorders. Progressive development of cognitive, emotional and behavior troubles leads to the loss of autonomy and to dependency of people, which corresponds to the dementia phase. Language disorders are among the first clinical cognitive signs of the disease. Our objective is to...

The multiligand Receptor for Advanced Glycation End products (RAGE) is involved in various pathophysiological processes, including diabetic inflammatory conditions and Alzheimers disease. Full-length RAGE, a cell surface-located type I membrane protein, can proteolytically be converted by metalloproteinases ADAM10 and MMP9 into a soluble RAGE form. Moreover, administration of recombinant solubl...

Traumatic brain injury (TBI) is an important problem of the healthcare system. A lPeading role in pathogenesis belongs to action shock wave upon skull and integuments, extending from impacted site, as well displacement rotation cerebral hemispheres relative fixed stem. As a result, cascade metabolic, biochemical inflammatory changes initiated, leading secondary damage. TBI, depending on its mec...

By the virtual screening method we have screened out Dihydrochalcone as a top-lead for the Alzheimer's disease using the database of about 32364 natural compounds. The binding affinity of this ligand to amyloid beta (Aβ) fibril has been thoroughly studied by computer simulation and experiment. Using the Thioflavin T (ThT) assay we have obtained the inhibition constant IC50 μM. This result is in...