BACKGROUND Adequate organ function and good performance status (PS) are common eligibility criteria for phase I trials. As inflammation is pathogenic and prognostic in cancer we investigated the prognostic performance of inflammation-based indices including the neutrophil (NLR) and platelet to lymphocyte ratio (PLR). METHODS We studied inflammatory scores in 118 unselected referrals. NLR norm...

Background: This study was aretrospective investigation aimed at determining the factors affecting the termination of peritoneal dialysis (PD) in patients with end stage renal failure (ESRF). Methods: Patients monitored in our PD Unit between 2000 and 2012 were included in the study. Demographic, clinical, and laboratory data were recorded for each patient. Treatment outcomes (technical surviva...

introduction: to evaluate the efficacy and safety of carboplatin plus paclitaxel in patients with advanced locoregional recurrence and metastatic endometrial cancer. patient and method: 32 eligible patients (median age 62, range 41-72) with measurable endometrial cancer were treated with carboplatin (auc= 6) and paclitaxel (175 mg/m 3 ) every 4 weeks for 6 cycles, or, until disease progression ...

objective(s): the present study aimed to evaluate the role of pretherapeutic 18fluorine-fluorodeoxyglucose positron emission tomographycomputed tomography (18f-fdg pet-ct) and maximum standardized uptake value (suvmax) in guiding the treatment strategy and predicting the prognosis of esophageal carcinoma, using the survival data of thepatients.methods: the present retrospective, cohort study wa...

Strategies to increase expanded criteria donor (ECD) transplantation are needed. We quantified the extent to which ECD kidneys provide recipients with a lifetime of allograft function by determining the difference between patient survival and death-censored allograft survival (graft survival). Initial analyses compared 5-year outcomes in the Eurotransplant Senior Program (European) and the Unit...

BACKGROUND This study was performed to assess the 2006 introduced ENETS TNM-classification with respect to patient survival and surgical approach for patients who underwent surgery for a neuroendocrine tumor of the pancreas (PNET). METHODS Between 2001 and 2010 38 patients after resection of a PNET were investigated regarding tumor localization and size. Further, patient survival with regards...

introduction: insertion or deletion of a guanine in -1607 at promoter region of matrix metalloproteinase-1 enzyme creates two allelic types for this gene in the population: 2g and 1g, respectively. 2g allele contains an extra binding site for ets transcription factors that this may increase the level of gene expression. therefore, aim of this study was investigation of the single guanine insert...

In this first report on the experience with renal transplantation in children and adolescents in southern Iran during the past five years, thirty-two patients (aged 5- 19 years old 18 males, 14 females) received renal allografts. Pretransplantation pathologic diagnoses by kidney biopsy were: membranoproliferative glomerulonephritis (MPGN), rapidly progressive glomerulonephritis (RPGN), chr...

emergency departments (eds) are the most challenging ward with respect to patient delay. the goal of this study is to present strategies that have proven to reduce delay and overcrowding in eds. in this review article, initial electronic database search resulted in a total of 1006 articles. thirty articles were included after reviewing full texts. inclusion criteria were assessments of real pat...

introduction: patient safety culture is an important part of improvement in the safety of health care. knowing its present status is required for development of safety culture. the present study aimed to evaluate the current status of patient safety culture in hospitals of three central provinces of iran. method: the present cross-sectional study was performed in teaching hospitals of tehran, a...