Delayed childbearing is a common phenomenon in industrialized countries. This review focuses on age-associated alterations of male fertility and genetic risks. Semen volume, sperm motility and sperm morphology decrease with age, whereas the data concerning sperm concentration are conflicting. The age-related changes of semen parameters reflect the histological modifications which are found to v...

STR, short tandem repeats, are well known as a type of powerful genetic marker and widely used in studying human population genetics. Compared with the conventional genetic markers, the mutation rate of STR is higher. Additionally, the mutations of STR loci do not lead to genetic inconsistencies between the genotypes of parents and children; therefore, the analysis of STR mutation is more suite...

BACKGROUND The role of social and family environments in the development of mental health problems among children and youth has been widely investigated. However, the degree to which parental working conditions may impact on developmental psychopathology has not been thoroughly studied. METHODS We conducted a case-control study of several mental health outcomes of 19,833 children of sawmill w...

ED FROM Frans EM, Sandin S, Reichenberg A, et al. Advancing paternal age and bipolar disorder. Arch Gen Psychiatry 2008;65:1034–40. Correspondence to: Emma M Frans, MMedSc, Department of Medical Epidemiology and Biostatistics, Karolinksa Institute, PO Box 281, SE-171 77 Stockholm, Sweden; [email protected] Source of funding: None reported. c A table is published online only at http://ebmh.bmj.co...

Variability in demographic traits between individuals within populations has profound implications for both evolutionary processes and population dynamics. Parental effects as a source of non-genetic inheritance are important processes to consider to understand the causes of individual variation. In iteroparous species, parental age is known to influence strongly reproductive success and offspr...

Paternal behavior and testosterone plasma levels in the Volcano Mouse Neotomodon alstoni (Rodentia: Muridae). Although initially it was thought that testosterone inhibited the display of paternal behavior in males of rodents, it has been shown that in some species high testosterone levels are needed for exhibition of paternal care. In captivity, males of Volcano Mouse (Neotomodon alstoni) provi...

Due to socioeconomic factors, more couples are choosing to delay conception than ever. Increasing average maternal and paternal age in developed countries over the past 40 years has raised the question of how aging affects reproductive success of males and females. Since oxidative stress in the male reproductive tract increases with age, we investigated the impact of advanced paternal age on th...