This paper compares two deconvolution methodologies used to estimate residence time distributions (RTD) in industrial closed-circuit ball mills. Parametric and non-parametric techniques were evaluated. Both allowed for direct RTD estimates from inlet outlet tracer measurements the mills, with no need mass balances nor assumptions correct effect of recirculation grinding circuits. Measurements c...

In this work, nanocomposites that combine mucopenetrating and mucoadhesive properties in a single system are proposed as innovative strategy to increase drug residence time the intestine following oral administration. To aim, novel chitosan (CH) sponges loaded with nanoemulsions (NE) were developed via freeze-casting technique. The NE mucopenetration ability was determined studying surface affi...