نتایج جستجو برای: pasat
تعداد نتایج: 205 فیلتر نتایج به سال:
OBJECTIVE Lamotrigine trial in SPMS was a randomised control trial to assess whether partial blockade of sodium channels has a neuroprotective effect. The current study was an additional study to investigate the value of neurofilament (NfH) and other biomarkers in predicting prognosis and/or response to treatment. METHODS SPMS patients who attended the NHNN or the Royal Free Hospital, UK, eli...
BACKGROUND Diabetes is associated with cognitive decline or dementia. The purpose of this study was to assess the executive functions and information processing in patients with type 2diabetes in comparison to pre-diabetic patients and normal subjects in Endocrine and Metabolism Research Center of Isfahan City from April to July 2011. METHODS The sample consisted of 32 patients with type 2 di...
AIM This 12-week, product-evaluation registry study aimed to compare the effects of supplementation with French Pine Bark Extract (Pycnogenol®) on cognitive function, attention, and mental performance in healthy professionals with increased oxidative stress in a professional context. METHODS Professionals were screened for increased oxidative stress: 60 subjects (range 35-55 years, no risk co...
BACKGROUND HIV-associated neurocognitive disorders (HAND) remain prevalent despite improved antiretroviral treatment (ART), and it is essential to have a sensitive and specific HAND screening tool. METHODS Participants were 200 HIV-infected US military beneficiaries, managed early in the course of HIV infection, had few comorbidities, and had open access to ART. Participants completed a compr...
Genetic susceptibility to multiple sclerosis (MS) is associated with the human leukocyte antigen (HLA) DRB1*1501 allele. Here we show a clear association between DRB1*1501 carrier status and four domains of disease severity in an investigation of genotype-phenotype associations in 505 robust, clinically well characterized MS patients evaluated cross-sectionally: (i) a reduction in the N-acetyl-...
OBJECTIVE Cannabis may alleviate some symptoms associated with multiple sclerosis (MS). This study investigated the effect of an orally administered standardized Cannabis sativa plant extract in MS patients with poorly controlled spasticity. METHODS During their inpatient rehabilitation programme, 57 patients were enrolled in a prospective, randomized, double-blind, placebo-controlled crossov...
BACKGROUND/OBJECTIVE Fatigue, cognitive, and affective disorders are relevant symptoms in multiple sclerosis (MS). The treatment with Natalizumab has a positive effect on physical disabilities in patients with relapsing-remitting MS (RRMS). Some studies describe improvements in cognition and fatigue over 1 year of treatment. Only little is known about longer treatment effects especially on fati...
INTRODUCTION The focus of this study was to examine oculomotor behavioral changes while subjects performed auditory and driving tasks. METHODS There were 13 participants who completed 3 10-min tasks consisting of driving only, the Paced Auditory Serial Addition Task (PASAT) only, and a dual task of both driving and auditory tasks. For each participant, changes in six measures were assessed as...
Air traffic controllers simultaneously develop complex and multiple tasks in the course of their activities. In this context, concern is raised over the high level of attention needed by these professionals which can ultimately be affected by stress and fatigue. Objectives The objective of this study was to assess attention level in air traffic controllers (ATCo). Methods 45 flight protecti...
OBJECTIVE Amino acids stimulate glucagon responses to hypoglycemia and may be utilized by the brain. The aim of this study was to assess the responses to hypoglycemia in nondiabetic and type 1 diabetic subjects after ingestion of an amino acid mixture. RESEARCH DESIGN AND METHODS Ten nondiabetic and 10 diabetic type 1 subjects were studied on three different occasions during intravenous insul...
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