English) A global mapping of early stage medical technology companies active in the neurology field has been implemented. The companies have emerging products and have undergone an evaluation by clinicians concerning the ability to provide clinical value for Swedish health care. The evaluation process has been executed by discussion with neurologists and neurosurgeons in combination with a lite...

A systematic evaluation of three different methods for generating induced pluripotent stem (iPS) cells was performed using the same set of parental cells in our quest to develop a feeder independent and xeno-free method for somatic cell reprogramming that could be transferred into a GMP environment. When using the BJ fibroblast cell line, the highest reprogramming efficiency (1.89% of starting ...

Amyloid protein aggregation is a key factor in the development of variety serious diseases humans, commonly named as amyloidoses (Alzheimers and Parkinsons diseases, type II diabetes, etc.), determinant protein-based inheritance lower eukaryotes. In yeast, translation termination Sup35 one most extensively studied amyloidogenic proteins. Aggregation (induction [PSI+] prion) decreases its functi...

D-Serine is an endogenous NMDA receptor co-agonist that activates synaptic NMDA receptors modulating neuronal networks in the cerebral cortex and plays a key role in long-term potentiation of synaptic transmission. D-serine is associated with NMDA receptor neurotoxicity and neurodegeneration and elevated D-serine concentrations have been associated with Alzheimer's and Parkinsons' diseases and ...

Oxidative modifications are the hallmark of oxidative imbalance in the brain of individuals with Alzheimers, Parkinsons and Prion diseases and their respective animal models. The aim of the research was to study the impact of aluminum chloride (AlCl3) administration in drinking water (7mg/kg body weight) and Dgalactose(i.p).The results revealed that the levels of lipidperoxidation were signific...