BACKGROUND Two recent studies identified a mutation (p.Asp620Asn) in the vacuolar protein sorting 35 gene as a cause for an autosomal dominant form of Parkinson disease . Although additional missense variants were described, their pathogenic role yet remains inconclusive. METHODS AND RESULTS We performed the largest multi-center study to ascertain the frequency and pathogenicity of the report...

A new idea for the identification of Parkinson tremor from essential tremor is presented in this paper. Segments of data of accelerometer and surface EMG signals are used with different wavelet bands for the idea of discrimination of Parkinson tremor from essential tremor. The data used are from the University of Kiel, Germany. The data are 41 training subjects: 21 with Essential-tremor (ET) an...

Artificial Neural Network (ANN)-based diagnosis of medical diseases has been taken into great consideration in recent years. In this paper, two types of ANNs are used to classify effective diagnosis of Parkinson's disease. Multi-Layer Perceptron (MLP) with back-propagation learning algorithm and Radial Basis Function (RBF) ANNs were used to differentiate between clinical variables of sampl...

BACKGROUND Prior studies suggest that serotoninergic neurotransmission reduces β-amyloid (Aβ) production. OBJECTIVE To determine whether serotoninergic system degeneration in Parkinson disease promotes Aβ deposition, using in vivo positron emission tomographic probes of serotonin system integrity and Aβ deposition. DESIGN, SETTING, AND PATIENTS Cross-sectional study of 13 subjects with Parkinso...

La enfermedad de Parkinson corresponde al desorden del movimiento más común y a la segunda neurodegenerativa frecuente Sistema Nervioso Central (SNC). Predomina en hombres edad usual presentación comprende entre los 65 70 años. En neuropatología intervienen niveles depletados dopamina, secundario las inclusiones citoplasmáticas alfa-sinucleína. Los síntomas motores cardinales corresponden bradi...

Recent development of high-resolution single-nucleotide polymorphism (SNP) arrays allows detailed assessment of genome-wide human genome variations. However, SNP data typically has a large number of SNPs (e.g., 400 thousand SNPs in genome-wide Parkinson disease SNP data) and a few hundred of samples. Conventional classification methods may not be effective when applied to such genome-wide SNP d...

Neurotransplantation as a treatment for Parkinson disease reached the stage of human trials over 15 years ago, but the field, which is still in its infancy, has encountered a number of roadblocks since then, both political and scientific. With hope that stem cells may be used as a new source of dopaminergic neurons to replace the degenerating nerve cells in Parkinson disease looming, it is crit...