BACKGROUND The aim of the study was to evaluate total parathyroidectomy with trace amounts of parathyroid tissue (30 mg) as a surgical option in secondary hyperparathyroidism (sHPT) treatment. METHODS From January 2008 to March 2012, 47 patients underwent parathyroidectomy. Comparisons of demographic data, symptoms, and preoperative or postoperative biochemistry were made between total parath...

Hypersecretion of parathormone in primary hyperparathyroidism is common, occurring in approximately 1 in 500 women and 1 in 2,000 men per year in their fifth to seventh decades of life. This has been suggested from the literature to be primarily the result of a parathyroid adenoma (80-85% of cases), hyperplasia involving more than 1 gland, usually with all 4 glands being involved (10-15% of cas...

Inactivating mutations of the multiple endocrine neoplasia 1 (MEN1) gene cause MEN1 syndrome, characterized by primary hyperparathyroidism (pHPT), and parathyroid and gastro-entero-pancreatic pituitary tumors. At present, only 14 cases of malignant parathyroid tumor have been associated with the syndrome, with 6 cases carrying an inactivating mutation of the MEN1 gene. The present study present...

Hereditary hyperparathyroidism, occurring as an isolated endocrinopathy was first described by Goldman and Smyth in 1936. They described primary hyperparathyroidism in two siblings. Jackson and Boonstra (1967) collected 21 families with 107 hyperparathyroid members from the literature, including eight unrelated families of their own, all discovered in a single centre over a 10-year period. This...

Parathyroid (PTH) exploration surgery carries the risk of developing post-operative thyroiditis due to vigorous manual manipulation of the thyroid gland during surgery. Post-operative thyroiditis has a wide spectrum of clinical manifestations. However, it remains underreported. Here, we describe a case of post-operative transient thyroiditis in a 33-year-old male who developed 3 days after para...

OBJECTIVE It is widely recognized that the diagnosis of parathyroid carcinoma (PC) is often difficult because of the overlap of characteristics between malignant and benign parathyroid tumors, especially at an early stage. Based on the identification of tumor suppressor gene HRPT2/CDC73 and its association with hereditary and sporadic PC, screening of gene mutations and detection of parafibromi...

Hereditary hyperparathyroidism, occurring as an isolated endocrinopathy was first described by Goldman and Smyth in 1936. They described primary hyperparathyroidism in two siblings. Jackson and Boonstra (1967) collected 21 families with 107 hyperparathyroid members from the literature, including eight unrelated families of their own, all discovered in a single centre over a 10-year period. This...

Purpose: To investigate the expression and exogenous effect of leptin hormone in diseased parathyroid glands at a basic science and clinical level. Introduction: Hyperparathyroidism (HPTH) is a common endocrine problem affecting 1 in 500 individuals who are typically female and over the age of 60. Combined effects of low calcium and vitamin D stimulating parathyroid activity and excess PTH secr...

Multiple endocrine neoplasia type 2A (MEN 2A) is most frequently caused by codon 634 activating mutations. Medullary thyroid carcinoma has occurred before the age of 2, with pheochromocytomas and primary hyperparathyroidism occurring later in childhood. We report cases of 4 siblings with C634Y-positive MEN 2A (all <11 years old): 3 with medullary thyroid carcinoma (1 had nodal metastasis, and a...