The clinical case described in this paper deals with a young female patient affected by primary hyperparathyroidism caused by an ectopic parathyroid adenoma of a supernumerary intrathymic parathyroid. The patient had hypercalcemia, in association with increased levels of parathormone, but was otherwise asymptomatic. Genetics tests for mutation of the MEN1, HRPT2, and CaSR genes were negative. S...

A hormonally active oxyphil adenoma of the parathyroid masqueraded as a thyroid nodule and was present as a palpable neck mass for more than six years prior to the onset of clinically obvious hyperparathyroidism. The slow evolution of the hyperparathyroidism in the presence of a relatively large adenoma was correlated with the presumptive low hormonal synthetic capacity of oxyphil cells that fo...

PURPOSE This article examines as to whether the Ki-67 index may be useful as a marker for cell proliferation, as well as to whether Ki-67 immunohistochemical expression and parathyroid hormone (PTH) levels are useful in distinguishing between parathyroid carcinoma (PC) and adenoma. METHODS A retrospective analysis of 50 patients (10 with PC and 40 with adenoma) who had been previously diagnos...

We report a case of a 66-year-old woman who developed hyperparathyroidism due to a large intrathyroid parathyroid adenoma with episodes of acute pancreatitis. She had previously been treated for acute pancreatitis twice. Serum calcium was 12.4 mg/dL, and intact parathyroid hormone was 253 pg/dL. Ultrasonography and computed tomography of the neck with contrast enhancement revealed a soft tissue...

Minimal-access or minimally invasive parathyroidectomy is replacing a bilateral neck exploration as the surgical approach of choice in primary hyperparathyroidism (pHPT). When a parathyroid adenoma is localized preoperatively, ideally with sestamibi combined with ultrasonography, results equivalent to a bilateral neck exploration can be achieved through an incision less than 2.5 cm. Minimal-acc...

Cervical hemorrhage due to non-traumatic, spontaneous rupture of the thyroid artery is rare, which usually results from arterial abnormalities or parathyroid or thyroid disorders. This report describes a 72-year-old woman who presented with a sore throat and slight neck swelling. Computed tomography (CT) revealed a large hematoma in the neck and mediastinum, due to extravasation from the major ...

Introduction. Primary hyperparathyroidism is rare pathology in children (2?5:100,000). In more than 85% of patients, a single adenoma present, and its extirpation usually the only treatment patient requires. approximately 15?80% cases, ectopic mediastinal parathyroid tissue can be found inside thymus. Case outline. Our was 13-year-old boy, who presented with multiple bone fractures previous per...

We evaluated the usefulness of 99mTc-methoxy-isobutyl-isonitrile (MIBI) dual phase scintigraphy for detecting hyperfunctioning parathyroid adenoma. We retrospectively reviewed 18 hyperparathyroid patients who received MIBI prior to neck exploration and compared the radiological findings of MIBI with ultrasonography (US) and magnetic resonance imaging (MRI). Fifteen patients were studied with MR...

Several imaging modalities exist for the detection of parathyroid adenomas in patients with primary hyperparathyroidism. Unlike solitary parathyroid adenoma, parathyroid hyperplasia in patients with secondary hyperparathyroidism hitherto is difficult to assess with any imaging modality. Our case of a young patient with chronic kidney failure illustrates that F-fluorocholine PET/MR might be an i...

J.C. Sillery D.R. DeLone K.M. Welker SUMMARY: We have encountered 2 cases of parathyroid adenomas that are atypical because of their large size, cystic character, and faint enhancement compared with the typical solid parathyroid adenomas. Specifically, the enhancement pattern of a typical parathyroid adenoma in a multiphasic scan demonstrates rapid arterial enhancement and rapid washout on dela...