OBJECTIVE Onconeuronal antibodies are important diagnostic tool in patients with suspicion of paraneoplastic neurological syndromes (PNS). However, their role in PNS pathophysiology and specificity for particular neurological manifestation remains unclear. The aim of this study was to evaluate onconeuronal and antineuronal antibodies in patients with pulmonary pathologies and suspected for PNS....

Hematopoietic cell transplantation (HCT) is the preferred treatment for an expanding range of neoplastic and nonmalignant conditions. Increasing numbers of solid organ transplantations (SOTs) add an additional population of immunosuppressed patients with multiple potential neurological problems. While the spectrum of neurological complications varies with conditioning procedure and hematopoieti...

Neurological syndromes commonly occur in patients with liver disease. A neurological syndrome associated with a liver disease may be a complication of the disease, it may be induced by a factor that also contributes to the disease—for example, alcohol—or it may have no relation to the presence of the liver disease. Neurological deficits associated with liver disease may aVect the CNS, the perip...

Introduction: Frontotemporal dementia (FTD) is a disease that encompasses several syndromes differ in their cognitive, behavioral, language signs, and motor phenomena. Only Alzheimer’s causes more early-onset cases than FTD. According to World Health Organization (WHO) projections, rates will double every 20 years reach 115.4 million people 2050, ranging from 3% 26%. The FTD spectrum three vari...

The association of high levels of autoantibodies to glutamic acid decarboxylase (GAD-ab) and stiff-person syndrome (SPS) is well known. However, the full spectrum of neurological syndromes associated with GAD-ab is not well established. In addition, these patients usually present type 1 diabetes mellitus (DM1) that could justify the presence of high GAD-ab levels. To clarify these issues, we re...

BACKGROUND Right temporal lobe lesion syndrome elicitation presents a clinical challenge. Aside from occasional covert quadrantanopias, heralding elementary neurological deficits are absent. AIM Isolated right and left temporal lobe stroke patients were analyzed for the panoply of known temporal and frontal cognitive and neuropsychiatric syndromes. METHODS Temporal lobe stroke patients were...

Convulsion is a serious neurological symptom with diverse underlying etiology ranging from metabolic causes to organic brain lesions. Congenital neuro-cutaneous syndromes are rare of seizures that manifest specific external features. This article reports 22-year-old man born non-consanguine parents, who presents recurrent commencing at the age one year along thephysical sign capillary hemangiom...

GABRB3 gene is a recently identified located in 15q12 chromosome and encodes for gamma-aminobutyric acid (GABA) receptor subunit beta-3 protein, which linked to the GABAA receptor. The believed share role inhibitory GABAergic synapses, GABA iron-gated channel function, possible cellular response histamine. β3 expressed cerebral grey matter, thalami, hippocampi, cerebellum, among other structure...

Background:Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has over 6 million deaths worldwide. Comorbidities like obesity, asthma, and neurological disorders are risk factors for illness in pediatric patients. The direct impact of COVID-19 on child mortality is limited, with only 0.4% occurring children under 20.
 Objective: To ...