Despite the known side effects of liver damage, among other issues, paracetamol (N-acetyl-p-aminophenol) continues to be one of the most commonly used drugs worldwide for conditions such as pain and fever and it is often purchased without medical prescription. It is usually administered as a tablet, but it is also available as solutions, suppositories and intravenous preparations. In addition, ...

The detection of an antibody against nucleoprotein (NP) of the avian influenza virus (AIV) was attempted by an electrochemical immunoassay by combining a secondary antibody-alkaline phosphatase conjugate and 4-aminophenylphosphate. Released 4-aminophenol was quantitated electrochemically, and the current derived from oxidation of the hydrolysis product increased linearly over a wide primary ant...

The stereochemical divergent synthesis of indolyl-pyrrolidines was accomplished using an imidazoline-aminophenol (IAP)-Ni(OAc)2 complex and a bis(imidazolidine)pyridine (PyBidine)-Cu(OTf)2 complex. The former catalyzed exo'-selective asymmetric [3 + 2] cyclization of iminoesters with indolyl nitroalkenes, and the latter catalyzed the reaction in an endo-selective manner. These catalysts are tol...

We evaluated a new method for measurement of acetaminophen. From acetaminophen, acetate and p-aminophenol are enzymically produced, and the latter product is determined colorimetrically by reaction with o-cresol and ammoniacal copper sulfate. The method is rapid and precise, and results compare well with those by spectrophotometric and liquid-chromatographic techniques. Major metabolites of ace...

In recent years strains previously grouped within Cryptococcus neoformans have been divided into two species C. neoformans and C. gattii, with Cryptococcus neoformans comprising serotypes A, D, and AD and C. gattii comprising serotypes B and C. Cryptococcus neoformans have also been subdivided into two varieties C. neoformans var. grubii, serotype A, and C. neoformans var. neoformans, serotype ...

The expeditious synthesis of 2-aryl-benzothia/(oxa)zoles was carried out by the condensation of 2-aminothiophenol/2-aminophenol and diverse aryl aldehydes in presence of Acacia concinna as a biocatalyst under microwave irradiation. The catalytic process is associated with excellent yields, greener reaction conditions and the environmentally friendly microwave technique which are the st...

Pseudomonas putida DLL-E4 can efficiently degrade para-nitrophenol and its intermediate metabolite hydroquinone. The regulation of para-nitrophenol degradation was studied, and PNP induced a global change in the transcriptome of P. putida DLL-E4. When grown on PNP, the wild-type strain exhibited significant downregulation of 2912 genes and upregulation of 845 genes, whereas 2927 genes were down...

a user-friendly and inexpensive ionic liquid-based single-drop microextraction (il-sdme) method was developed to preconcentrate trace amounts of aminophenol isomers (aps) from human urine, hair dye and water samples prior to analysis by high performance liquid chromatography-ultraviolet spectrophotometry detection (hplc-uv). under optimum conditions (i.e., 3.5 µl of 1-hexyl-3-methylimidazolium ...

Here a novel electrochemical method for the rapid detection of anti-HIV antibodies in serum is presented. The novelty lies in the combination of allosteric enzymes and coulometry to yield a fast, simple and reliable HIV diagnostic method. We have used a previously developed beta-galactosidase enzyme that is efficiently activated by anti-HIV antibodies directed against a major B-cell epitope of ...

The aminophenol (AP) catabolic operon in Pseudomonas putida HS12 mineralizing nitrobenzene was found to contain all the enzymes responsible for the conversion of AP to pyruvate and acetyl coenzyme A via extradiol meta cleavage of 2-aminophenol. The sequence and functional analyses of the corresponding genes of the operon revealed that the AP catabolic operon consists of one regulatory gene, nbz...