We provide an overview of how the underlying philosophy of chemometrics is integrated throughout metabonomic studies. Four steps are demonstrated: (1) definition of the aim, (2) selection of objects, (3) sample preparation and characterization, and (4) evaluation of the collected data. This includes the tools applied for linear modeling, for example, Statistical Experimental Design (SED), Princ...

SCORES A disability index was constructed using all questions for each type of disability in the PALS 2001 questionnaire. Points were assigned to each question based on severity, the maximum score being given for someone who is totally disabled in all area. For each type of disability, there are essentially two types of questions: intensity and frequency. Some intensity questions are asked in d...

A novel scheme for modeling 3D QSAR has been developed. A method involving multiple self-organizing neural network adjusted to be analyzed by the PLS (partial least squares) analysis was used to model 3D QSAR of the selected colchicinoids. The model obtained allows the identification of some structural determinants of the biological activity of compounds.

This research examines the interrelationships of trust, brand awareness/associations, perceived quality and brand loyalty in building Internet banking brand equity. The model was based on data from customers using online banking (customers of an international bank) using the PLS technique. The results suggest that perceived quality and brand loyalty are more important to explain the Internet ba...

Vincenzo Esposito Vinzi; Giorgio Russolillo; Laura Trinchera ESSEC Business School of Paris, Avenue Bernard Hirsch B.P. 50105 Cergy-Pontoise 95021, France. Università degli Studi di Napoli \Federico II" Dipartimento di Matematica e Statistica Via Cintia Complesso Monte S. Angelo, Napoli 80126, Italy. Università degli Studi di Macerata Dipartimento di Studi sullo Sviluppo Economico Piazza Oberda...

A new method orthogonal projection to latent structures (O-PLS) combined with artificial neural networks is investigated for non-destructive determination of ebastine powder via near-infrared (NIR) spectroscopy. The modern NIR spectroscopy is efficient, simple and non-destructive technique, which has been used in chemical analysis in diverse fields. Being a preprocessing method, O-PLS provides ...

PLS dimension reduction is known to give good prediction accuracy in the context of classification with high-dimensional microarray data. In this paper, PLS is compared with some of the best state-of-the-art classification methods. In addition, a simple procedure to choose the number of components is suggested. The connection between PLS dimension reduction and gene selection is examined and a ...

Now six months old, ALSUntangled (1) has 85 followers on twitter, and receives weekly questions about alternative and off-label ALS therapies. Our NING has 40 ALS clinician-scientists from four countries examining these therapies, with 18 active discussions. New discussions underway since our last update (2) include: intravenous glutathione, the Lourdes ALS Miracle, and the Nepsis Institute. Re...

Purpose – The purpose of this paper is to contribute to the corporate marketing literature by examining how an individual’s identification with a company influences their willingness to invest in the company’s shares. Design/methodology/approach – A set of hypotheses was developed, based on theory, and survey data were obtained from 440 individuals in order to test the hypotheses. The data pert...