In an accompanying paper the relationship of the Shope virus engendering papillomas to the cancers deriving from these growths has been approached from the side of the virus. I t will now be considered in the light of certain data provided by the tumors themselves. The papilloma is known to be characterized by those traits of appearance and behavior which distinguish neoplasms from other pathol...

Background: Vaccines based on virus-like particles are effective against Human Papilloma Virus (HPV) infection; however, they have not shown a therapeutic effect against HPV-associated diseases. New immunotherapy strategies based on immune responses against tumor antigens can positively affect the clearance of HPV-associated lesions. Objective: To generate two therapeutic fusion DNA vaccines (o...

A papilloma has been observed in wild cottontail rabbits and has been found to be transmissible to both wild and domestic rabbits. The clinical and pathological pictures of the condition have been described. It has been found that the causative agent is readily filtrable through Berkefeld but not regularly through Seitz filters, that it stores well in glycerol, that it is still active after hea...

In 1933, Shope (14) described a virus-induced papilloma occurring naturally in the cottontailS rabbit (genus Sylvilagus) and transmissible to the domestic rabbit (genus Oryctolagus). Later, Rous and Beard (13) found that the experimentally in duced papillomas in domestic rabbits often pro gressed to carcinomas; and Syverton and Berry (16,17)observedthesamephenomenon incotton tail rabbits. Becau...

Reference 1. Hidalgo-Tenorio C, Rivero-Rodriguez M, Gil-Anguita C, Esquivias J, López-Castro R, RamírezTaboada J, et al. (2015) The Role of Polymerase Chain Reaction of High-Risk Human Papilloma Virus in the Screening of High-Grade Squamous Intraepithelial Lesions in the Anal Mucosa of Human Immunodeficiency Virus-Positive Males Having Sex with Males. PLoS ONE 10(4): e0123590. doi:10.1371/ jour...

Negative staining is used widely for the electron microscopic observation of virus particles in partially purified suspensions of virus (S. Brenner and R. W. Home, Biochim. Biophys. Acta 34:103, 1959) and in thinly spread cell preparations of infected tissue (D. F. Parsons, J. Cell Biol. 16:620, 1963). A modification of the negative-staining technique is described in the following paragraphs. T...

In 1933, Shope (14) described a virus-induced papilloma occurring naturally in the cottontailS rabbit (genus Sylvilagus) and transmissible to the domestic rabbit (genus Oryctolagus). Later, Rous and Beard (13) found that the experimentally in duced papillomas in domestic rabbits often pro gressed to carcinomas; and Syverton and Berry (16,17)observedthesamephenomenon incotton tail rabbits. Becau...

Human papilloma virus-induced recurrent laryngeal papillomatosis is considered a troublesome and dangerous disease, because it can cause airway obstruction. Better understanding of metabolic pathways followed under pathological conditions can contribute to improved therapies by which growth and recurrence may be obviated. Part I of this study presents a clinically relevant total lipid fatty aci...

To determine the mechanisms of cell death in rhabdovirus-infected cells, we studied the infection of the epithelial papilloma of carp cell line with spring viremia of carp virus. Studies using electron microscopy, confocal microscopy, and agarose gel electrophoresis revealed changes in cell morphology and DNA fragmentation indicative of apoptosis. The virus-induced apoptosis was inhibited in ce...