Since methotrimeprazine proved to be both an effective tranquilizer and analgesic, its effect in a tranquilizing dose of 0.15 mg/kg on the arterial blood gases was determined in human volunteers. Because of the known potentiating effect of some phenothiazines on the narcotic-analgesic induced respiratory depression and analgesia, the effect of methotrimeprazine on the meperidine-induced respira...

BACKGROUND The optimal method for out-of-hospital ventilation during cardiopulmonary rescue (CPR) is controversial. The aim of this study was to test different modes of ventilation during CPR for a prolonged period of 60 min. METHODS Pigs were randomized to four groups after the induction of ventricular fibrillation, which was followed by one hour of mechanical cardiac compressions. The study...

We have studied the effects of anaesthesia on atelectasis formation and gas exchange in 45 patients of both sexes, smokers and nonsmokers, aged 23-69 yr. None of the patients showed clinical signs of pulmonary disease, and preoperative spirometry was normal. In the awake patient, partial pressure of arterial oxygen (PaO2) decreased with increasing age (P less than 0.001) and the alveolar-arteri...

Recertification for long-term oxygen therapy (LTOT) has been recommended for patients who are clinically unstable when home oxygen therapy is begun. Periods of observation for clinical stability have ranged from three weeks to three months in large multicenter clinical trials. There is concern, however, that an increase in arterial oxygen tension occurring after three months may be related to t...

Objective: to identify the association of hyperoxia at time Intensive Care Unit (ICU) admission with clinical outcomes in adult patients on invasive mechanical ventilation and respiratory dysfunction defined by a PaO2/FIO2 ratio (P/F) below 300. Methods: retrospective cohort observational study data from admitted general ICU, 8 beds university hospital. Hyperoxia was as PaO2 > 120mmHg were c...

Background. Xenon-in-oxygen is a high density gas mixture and may improve PaO2/FiO2 ratio in morbidly obese patients uniforming distribution of ventilation during anesthesia. Methods. We compared xenon versus sevoflurane anesthesia in twenty adult morbidly obese patients (BMI > 35) candidate for roux-en-Y laparoscopic gastric bypass and assessed PaO2/FiO2 ratio at baseline, at 15 min from induc...

Transcutaneous oxygen (TcPo2) and carbon dioxide (TcPco2) tensions were compared with arterial values in 23 children aged 4 months to 14 years, all requiring some form of respiratory support, but not in shock. Electrodes were placed on the upper chest and were heated to 45 degrees C. For TcPo2 and arterial oxygen (Pao2) a tight linear correlation over the range 6 to 14 kPa was found. Arterial c...

One of the proposed mechanisms of ventilator-associated lung injury is cyclical recruitment of atelectasis. Collapse of dependent lung regions with every breath should lead to large oscillations in arterial PO2 (PaO2) as shunt varies throughout the respiratory cycle. We placed a fluorescent-quenching PO2 probe in the brachiocephalic artery of 6 anesthetized rabbits after saline lavage. Using pr...