OBJECTIVE We investigated the deficit in the recognition of facial emotions in a sample of medicated, stable Korean patients with schizophrenia using Korean facial emotion pictures and examined whether the possible impairments would corroborate previous findings. METHODS Fifty-five patients with schizophrenia and 62 healthy control subjects completed the Facial Affect Identification Test with...

Sir: We read with great interest the recent article by Zhong and colleagues 1 reporting results of a trial comparing quetiapine and risperidone for the treatment of schizophrenia. In that double-blind, 8-week study, there was a statistically significant difference favoring risperidone on the change at endpoint on the Positive and Negative Syndrome Scale (PANSS) positive symptoms subscale (an a ...

Centbutindole is a new antipsychotic agent related to butyrophenone group. The drug is dopamine antagonist but it also blocks 5HT(2) receptors. Clinically the drug has passed through phase I, II & III clinical trials successfully and it has shown effective antipsychotic activity in schizophrenic patients. In the present study the drug was compared with risperidone in a double blind manner for a...

BACKGROUND Lifestyle moderate-intensity physical activity can lower the risk of over twenty chronic health conditions, whilst inactivity reduces daily functioning and physical health of individuals living with schizophrenia. This study conducted in 2014 examines the effect of structured walking participation on QOL, psychosocial functioning and symptoms in Hospital Permai, one of the largest ps...

BACKGROUND In patients with schizophrenia, early non-response to oral antipsychotic therapy robustly predicts subsequent non-response to continued treatment with the same medication. This study assessed whether early response predicted later response when using a long-acting injection (LAI) antipsychotic. METHODS Data were taken from an 8-week, randomized, double-blind, placebo-controlled stu...

BACKGROUND The limitations of antipsychotics for treatment of schizophrenia have led to investigation of the usefulness of pharmacological augmentation strategies. Clinical studies have provided evidence for glutamate abnormalities in schizophrenia. Topiramate is an anticonvulsant drug with alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor antagonist properties; therefore, the o...

Objective: Quantitative electroencephalography (QEEG) is a well established method for evaluating brain functioning. Abnormal oscillatory activity measured with QEEG during resting state has been consistently reported in patients with schizophrenia. We aimed to examine whether resting state EEG is associated with 1 year outcome in patients with first episode psychosis (FEP). Method: Twenty five...

Objective: Quantitative electroencephalography (QEEG) is a well established method for evaluating brain functioning. Abnormal oscillatory activity measured with QEEG during resting state has been consistently reported in patients with schizophrenia. We aimed to examine whether resting state EEG is associated with 1 year outcome in patients with first episode psychosis (FEP). Method: Twenty five...

OBJECTIVE This 52-week randomized, double-blind, flexible-dose, multicenter study evaluated the overall effectiveness (as measured by treatment discontinuation rates) of olanzapine, quetiapine, and risperidone in patients early in the course of psychotic illness. METHOD Patients were randomly assigned to treatment with olanzapine (2.5-20 mg/day), quetiapine (100-800 mg/day), or risperidone (0...

BACKGROUND Cognitive deficits in schizophrenia are associated with psychosocial deficits that are primarily responsible for the poor long-term outcome of this disease. Auditory sensory gating P50 deficits are correlated with neuropsychological deficits in attention, one of the principal cognitive disturbances in schizophrenia. Our studies suggest that the alpha7 nicotinic acetylcholine receptor...