نتایج جستجو برای: pancreatic β cell

تعداد نتایج: 1877157  

2012
Lynda Elghazi Aaron P. Gould Aaron J. Weiss Daniel J. Barker John Callaghan Darren Opland Martin Myers Corentin Cras-Méneur Ernesto Bernal-Mizrachi

In settings of increased insulin demand, failure to expand pancreatic β-cells mass leads to diabetes. Genome-wide scans of diabetic populations have uncovered several genes associated with susceptibility to type 2 diabetes and a number of them are part of the Wnt signaling. β-Catenin, a Wnt downstream effector participates in pancreatic development, however, little is known about its action in ...

2016
Shinji Kume Motoyuki Kondo Shiro Maeda Yoshihiko Nishio Tsuyoshi Yanagimachi Yukihiro Fujita Masakazu Haneda Keiko Kondo Akihiro Sekine Shin-ich Araki Hisazumi Araki Masami Chin-Kanasaki Satoshi Ugi Daisuke Koya Sawako Kitahara Kiyosumi Maeda Atsunori Kashiwagi Takashi Uzu Hiroshi Maegawa

Glucose-stimulated insulin secretion (GSIS) by pancreatic β cells is biphasic. However, the physiological significance of biphasic GSIS and its relationship to diabetes are not yet fully understood. This study demonstrated that impaired first-phase GSIS follows fasting, leading to increased blood glucose levels and brain glucose distribution in humans. Animal experiments to determine a possible...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2015
Mario Rossi Inigo Ruiz de Azua Luiz F Barella Wataru Sakamoto Lu Zhu Yinghong Cui Huiyan Lu Heike Rebholz Franz M Matschinsky Nicolai M Doliba Adrian J Butcher Andrew B Tobin Jürgen Wess

G protein-coupled receptors (GPCRs) regulate virtually all physiological functions including the release of insulin from pancreatic β-cells. β-Cell M3 muscarinic receptors (M3Rs) are known to play an essential role in facilitating insulin release and maintaining proper whole-body glucose homeostasis. As is the case with other GPCRs, M3R activity is regulated by phosphorylation by various kinase...

Journal: :Anticancer research 2013
Zheng Wang Qingyong Ma Pei Li Huanchen Sha Xuqi Li Jun Xu

AIM The stromal cell-derived factor-1 (SDF-1)/C-X-C chemokine receptor type 4 (CXCR4) axis and Wingless and INT-1 (Wnt)/β-catenin pathway has been related to cancer progression. The aim of this study was to investigate the expression of CXCR4 and β-catenin in pancreatic cancer. PATIENTS AND METHODS A total of 48 pancreatic cancer samples and 8 normal pancreatic tissues were selected to detect...

2016
Lu Liu Qiaoming Zhi Meng Shen Fei-Ran Gong Binhua P. Zhou Lian Lian Bairong Shen Kai Chen Weiming Duan Meng-Yao Wu Min Tao Wei Li

The WNT/β-catenin pathway plays an important role in pancreatic cancer carcinogenesis. We evaluated the correlation between aberrant β-catenin pathway activation and the prognosis pancreatic cancer, and the potential of applying the β-catenin pathway inhibitor FH535 to pancreatic cancer treatment. Meta-analysis and immunohistochemistry showed that abnormal β-catenin pathway activation was assoc...

2017
Ke Xu Dezhi Bian Lanxiang Hao Fei Huang Min Xu Jie Qin Yanmei Liu

Loss of pancreatic β cells is involved in pathogenesis of gestational diabetes mellitus (GDM). Recently, several studies have elucidated the connection between microRNAs (miRNAs) and diabetes mellitus (DM), but the role of miRNAs in GDM remains unclear. The aim of this study was to evaluate the potential functions of miRNAs in GDM and to investigate the underlying mechanisms of action. First, w...

2013
Kohtaro Minami Susumu Seino

Newly generated insulin-secreting cells for use in cell therapy for insulin-deficient diabetes mellitus require properties similar to those of native pancreatic β-cells. Pancreatic β-cells are highly specialized cells that produce a large amount of insulin, and secrete insulin in a regulated manner in response to glucose and other stimuli. It is not yet explained how the β-cells acquire this co...

2017
Jian Wan Yan Huang Pengcheng Zhou Yibing Guo Cen Wu Shajun Zhu Yao Wang Lei Wang Yuhua Lu Zhiwei Wang

Diabetes mellitus is a disease which has affected 415 million patients in 2015. In an effort to replace the significant demands on transplantation and morbidity associated with transplantation, the production of β-like cells differentiated from induced pluripotent stem cells (iPSCs) was evaluated. This approach is associated with promising decellularized scaffolds with natural extracellular mat...

Journal: :Current protocols 2021

Streptozotocin (STZ) is an antibiotic that causes pancreatic islet β-cell destruction and widely used experimentally to produce a model of type 1 diabetes mellitus (T1DM). Detailed in this article are protocols for producing STZ-induced insulin deficiency hyperglycemia mice rats. Also described creating animal models 2 using STZ. These animals employed assessing the pathological consequences sc...

2017
Feorillo Galivo Eric Benedetti Yuhan Wang Carl Pelz Jonathan Schug Klaus H Kaestner Markus Grompe

The gallbladder and cystic duct (GBCs) are parts of the extrahepatic biliary tree and share a common developmental origin with the ventral pancreas. Here, we report on the very first genetic reprogramming of patient-derived human GBCs to β-like cells for potential autologous cell replacement therapy for type 1 diabetes. We developed a robust method for large-scale expansion of human GBCs ex viv...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید