نتایج جستجو برای: pamam dendrimers
تعداد نتایج: 3360 فیلتر نتایج به سال:
Drug delivery into the central nervous system (CNS) is challenging due to the blood-brain barrier (BBB) and drug delivery into the brain overcoming the BBB can be achieved using nanoparticles such as dendrimers. The conventional cationic dendrimers used are highly toxic. Therefore, the present study investigates the role of novel mixed surface dendrimers, which have potentially less toxicity an...
The ability of poly(amido amine) (or PAMAM) dendrimers to condense semiflexible dsDNA and penetrate cell membranes gives them great potential in gene therapy and drug delivery but their high positive surface charge makes them cytotoxic. Here, we describe the effects of partial neutralization by acetylation on DNA condensation using light scattering, circular dichroism, and single molecule imagi...
The synthesis, characterization, and metal-binding studies of chelate-functionalized dendrimers is reported. Salicylate, catecholate, and hydroxypyridinonate bidentate chelators have been coupled to the surface of both poly(propyleneimine) (Astramol) and poly(amidoamine) (Starburst, PAMAM) dendrimers up to the fifth generation (64 endgroups). A general method has been developed for the facile a...
Polycationic dendrimer-based gene transfer is one of the most important biological applications of dendrimers, which involves electrostatic interactions between the positively charged dendrimer end groups and the negatively charged phosphate groups in DNA. Such features could also be used to bind biologically important RNA molecules, which are emerging as both important therapeutic targets and ...
1. Materials: .................................................................................................................... 2 2. Structure of PAMAM dendrimers: ............................................................................. 2 3. Instrumentation: .......................................................................................................... 2 4. Experimental condi...
In this work, three different generations of Poly(amidoamine) dendrimers (PAMAM) decorated on magnetic Fe3O4 composites (Fe3O4@SiO2–G1, Fe3O4@SiO2–G3, Fe3O4@SiO2–G5) were fabricated and characterized by FTIR, XRD, TEM, TGA, VSM XPS. The obtained used for Cr(VI) removal. Batch adsorption studies showed that the reached equilibrium within 60 min, optimal pH was 3.0. result kinetics simulated pseu...
A product showing strong blue photoluminescence was obtained by oxidation of OH-terminated PAMAM dendrimers, such as G4-OH, G2-OH, and G0-OH, with HAuCl4 or (NH4)2S2O8. The fluorescence emission spectrum peaked at 450 nm, while the excitation maximum was at 380 nm, independent of the generation of dendrimer. The product also shows two weak electrogenerated chemiluminescence (ECL) signals upon c...
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