We report the first radiocarbon datings and carbon (δ13C) oxygen (δ18O) stable isotopes data to reconstruct paleoecology of medium large herbivorous mammals from late Quaternary southwestern Amazon (Acre Rondônia states, Brazil). AMS 14C dates for Neochoerus sp. (29,072 - 27,713 Cal yr BP), Notiomastodon platensis (25,454 24,884 BP) Eremotherium laurillardi (11,320 11,131 support Lujanian ages....