BACKGROUND The continuous emergence of multidrug-resistant (MDR) bacteria drastically reduced the efficacy of our antibiotic armory and consequently, increased the frequency of therapeutic failure. The search for bioactive constituents from endophytic fungi against MDR bacteria became a necessity for alternative and promising strategies, and for the development of novel therapeutic solutions. W...

A novel triterpene, 2alpha,3beta,20,23-tetrahydroxyurs-28-oic acid (1), was isolated from the aerial part of Centella asiatica. Its structure was elucidated by spectroscopic methods, including 2D-NMR spectra. It displayed no activity against Hela and A549 cell lines at concentrations of 10 and 30 microg/mL, respectively.

Article history: Received 31 August 2016 Accepted 16 September 2016 Available online 03 October 2016 Coastal sandy beaches are considered to be an integral part of the coastal ecosystems in marine environment. Sandy beach is an extremely dynamic environment where sand and water are always in motion. There are several fauna and flora occurring in this zone. The mole crab, Emerita asiatica is one...

Inter-disciplinary Program in Physiology, Graduate School, Chulalongkorn University, Bangkok, Thailand. Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand. Cell-based Drug and Health Product Development Research Unit., Chulalongkorn University, Bangkok, Thailand. Faculty of Dentistry, Mahidol University, Bangkok, Thailand D...

Centella asiatica, commonly known as Gotu kola, has been widely used as a traditional herb for decades. Yet, the study on which compounds or compound combinations actually lead to its brain benefits remains scarce. To study the neuroprotection effects of Centella asiatica, neuronal differentiation of PC12 cells was applied. In our pilot study, we isolated 45 Centella asiatica fractions and test...

Oxidative stress in liver injury is a major pathogenetic factor in the progression of liver damage. Centella asiatica (L.) Urban, known in the United States as Gotu kola, is widely used as a traditional herbal medicine in Chinese or Indian Pennywort. The efficacy of Centella asiatica is comprehensive and is used as an anti‑inflammatory agent, for memory improvement, for its antitumor activity a...

Various studies have already been performed involving the whole aerial parts of Centella asiatica (L.) (Umbelliferae), commonly known as gotukola or jalbrahmi and thus the present investigation has been carried out for the phytochemical study of ethanolic extract of the aerial parts of Centella asiatica. To perform this activity, the drug (1.5kg) was exhaustively extracted in 95% ethanol using ...

India has a diverse variety of medicinally important plants which have been claimed with beneficial therapeutic effects along with better tolerability in terms of side effects. G. asiatica also known as phalsa, a member of tiliaceae family is a small fruit crop cultivated in warmer season and is known to contain cyanidin 3glucoside, vitamin C, minerals. A brief review of work so far carried out...

A new species, Garcinia hopii H.Toyama & V.S.Dang is described from Bidoup Nui Ba National Park, southern Vietnam. This species is similar to Garcinia hendersoniana Whitmore but differs from that species in having larger leaves, clustered pistillate flowers, a greater number of sterile anthers and a larger stigma of young fruits. A description, preliminary conservation assessment, illustration,...

Natural products have been a great source of many small molecule drugs for various diseases. In spite of recent advances in biochemical engineering and fermentation technologies that allow us to explore microorganisms and the marine environment as alternative sources of drugs, more than 70 % of the current small molecule therapeutics derive their structures from plants used in traditional medic...