High-dose chemotherapies to treat multiple myeloma (MM) can be life-threatening due to toxicities to normal cells and there is a need to target only tumor cells and/or lower standard drug dosage without losing efficacy. We show that pharmacologically-dosed ascorbic acid (PAA), in the presence of iron, leads to the formation of highly reactive oxygen species (ROS) resulting in cell death. PAA se...

Based on the knowledge that cationic polymers with different topographical structures behave differently in gene transfection process, herein, we synthesized three biodegradable poly(amido amine)s (PAAs) with the same repeating units and molecular weights except for degree of branching: linear PAA (LPAA), low-branched PAA (LBPAA), and high-branched PAA (HBPAA). We found that LBPAA could more ef...

Two established delignification methods employing sodium chlorite-acetic acid (SC/AA) and peracetic acid (PAA) are often used, and are reportedly highly selective. However, these reports are mostly for highly recalcitrant and unpretreated softwoods and hardwoods species, and information for less recalcitrant lignocellulosic feedstocks and pretreated biomass is scarce. Furthermore, the effects o...

1. The content of total pantothenic acid (PaA) in two foodstuffs of microbial origin was measured by standard microbiological and chick biological assays. 2. Substantially and consistently higher values were found by the chick assay than by the microbiological determination, indicating that PaA-containing compounds were present that were not utilized by the test micro-organisms but were availab...

A novel and highly sensitive fiber-optic DNA sensor based on a thin-core fiber modal interferometer (TCFMI) is demonstrated by using a layer-by-layer (LbL) self-assembly technology. Poly(ethylenimine) (PEI), poly(acrylic acid) (PAA) and single-stranded DNA (ssDNA) were used for the preparation of a polyelectrolyte multilayer film for DNA detection. The film thickness was measured through a surf...

Extremely to slightly halophilic bacteria were tested for susceptibility to two sterilizing agents, peracetic acid (PAA) and ethylene oxide (ETO). PAA susceptibility was explored by two methods: an agar plate (constant pH of 7.2) and a filter strip (constant incubation period of 37 days); 100% susceptibility was obtained by both methods. The dosage (0.5 ml/min) was applied to a filter pad in a ...

This paper dwells on the results of the experimental study of three binary mixture i.e., Para-azoxy anisole (PAA)-Benzene (C6H6), Para-azoxy anisole (PAA)-Carbon tetrachloride (CCl4), Para-azoxy anisole (PAA)-1-4 Dioxane (C4H8O2) at 303K, 303K and 304K respectively. The ultrasonic velocity (u) and density (ρ) have been measured in different mole fraction. From these values the acoustical parame...

Multilayered thin films containing poly(allylamine) (PAA) and brilliant yellow (BY) were prepared on a quartz slide by a layer-by-layer (LBL) deposition technique. The UV-visible spectra of the PAA/BY films were sufficiently changed depending upon the pH value of the solution in which the film was immersed. The response of the PAA/BY films was very fast (within a second) upon pH change from 9.0...

The development of hydrogel electrolytes plays a critical role in high-performance flexible supercapacitor devices. Herein, composite electrolyte polyacrylic acid (PAA) and graphene oxide (GO) has been successfully prepared, where the oxygen-containing functional groups GO may crosslink form hydrogen bonds with carboxyl on molecular chain PAA, thereby significantly enhancing mechanical properti...