A central issue in systems biology is the study of efficient methods to infer fluxes of biological reactions starting from experimental data. Among the different techniques proposed in the last years, in the theory of Metabolic P systems Log-Gain principles have been introduced, which prove to be helpful for deducing biological fluxes from temporal series of observed dynamics. However, crucial ...

In this paper we describe a high-performance multicompartment stochastic simulator called mcss which we have developed and are using to execute large-scale systems biology models. Our eventual goal is to be able to simulate multiscale systems biology models containing millions of compartments each of them hosting large biological regulatory networks. We show that mcss is able to accurately and ...

Electro-osmosis is the flow produced by the action of an electric field on a fluid with a net charge, which is created by the Zeta potential and confined in the Debye layer. This basic phenomenon in the electro-kinetic transport plays an important role in the microfluidic systems being explored today because it can be applied to a variety of MEMS devices. This paper presents global and point-wi...

Two classes of tissue P systems based on evolution communication rules are introduced, some results are proved, but many more are listed as further research problems. A framework to develop population P systems is defined and a number of variants formulated with a strong biological motivation.

In this paper, four restricted variants of the generalised communicating P systems are considered and their computational power is investigated. In all these cases better results are produced, with respect to the number of cells involved, than those provided so far in the literature. Connections between the variants considered and recently introduced kernel P systems are investigated.