Positive modulators of the excitatory amino acid receptor a-Amino-3hydroxy-5-methyl-4-isoxazole Propionate (AMPA) has been shown to enhance memory and learning tasks performed by rodents and by human subjects. A new class of AMPA receptor modulators has been recently synthesized. These compounds belong to the class of organic nitrate ester of the nitroglycerine family and are designated GT-2 1-...

BACKGROUND The effectiveness of an intervention in clinical practice is often reduced compared to the efficacy demonstrated in a randomised controlled trial (RCT). In this comparative effectiveness study, the RCT-proven efficacy of a diabetes education programme for type 1 diabetic patients (PRIMAS) was compared to the effectiveness observed in an implementation trial (IT) under routine care co...

BACKGROUND This study is a part of the randomized controlled trial, the Trondheim Hip Fracture Trial, and it compared physical behavior and function during the first postoperative days for hip fracture patients managed with comprehensive geriatric care (CGC) with those managed with orthopedic care (OC). METHODS Treatment comprised CGC with particular focus on mobilization, or OC. A total of 3...

BACKGROUND A substantial minority of adolescents suffer from depression and it is associated with increased risk of suicide, social and educational impairment, and mental health problems in adulthood. A recently conducted randomized controlled trial in England evaluated the effectiveness of a manualized universally delivered age-appropriate CBT programme in school classrooms. The cost-effective...

and Applied Analysis 3 Table 1: Solitary wave Amp. 0.3 and the errors in L2 and L∞ norms for u, Q 1 , Q 2 , and Q 3 at t = 20, h = 0.125, Δt = 0.1, and −40 ≤ x ≤ 60. Method Time Q 1 Q 2 Q 3 L 2 for u L∞ for u Our method 0 3.9797 0.8104 2.5787 0 0 4 3.9797 0.8104 2.5786 3.6304e − 004 5.2892e − 005 8 3.9797 0.8104 2.5786 7.2873e − 004 5.8664e − 005 12 3.9797 0.8104 2.5787 1.0817e − 003 6.3283e − ...

Central and peripheral cardiovascular adaptations to 12 weeks of intense swim training were characterized in 12 previously sedentary middle-aged men and women. Peak oxygen uptake (VO2) during upright bicycle exercise improved from 29.2 +/- 5.6 to 34.7 +/- 6.7 ml/kg/min (mean +/- SD, p less than .01) because of similar increases in peak cardiac output (CO) and calculated arteriovenous oxygen dif...

BACKGROUND Despite concerns that facilitating informed choice would decrease diabetes screening uptake, 'informed choice' invitations that increased knowledge did not affect attendance (the DICISION trial). We explored possible reasons using data from an experimental analogue study undertaken to develop the invitations. We tested a model of the impact on knowledge, attitude and intentions of a ...

HYPOTHESIS Gastroesophageal reflux (GER) is a common condition in childhood that frequently requires operative treatment. The 360 degrees Nissen fundoplication (NF) has been the standard operation for GER, but is associated with substantial rates of recurrence, "gas bloat," gagging, and dysphagia. I believe that the Toupet fundoplication (TF), a 270 degrees posterior wrap originally described i...