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BACKGROUND Acetaminophen (N-acetyl-p-aminophenol [APAP]) is a widely used medication that can cause hepatotoxicity. We examined characteristics and outcomes of children with chronic exposure (CE) to APAP in the multinational Pediatric Acute Liver Failure (PALF) Study. METHODS A total of 895 children enrolled from 2002 to 2009 were grouped by APAP exposure history as: CE (received multiple dos...
INTRODUCTION The purpose of this study was to assess torque and force for simulated canal preparation with a new root canal instrument, ProTaper Next. METHODS Six sets of ProTaper Next Instruments (X1-X5) were used to prepare 36 artificial canals. Files were divided into 6 groups. Different settings of rotations per minute (250, 300, and 350 rpm) and numbers of in-and-out movements to reach w...
BACKGROUND People with intellectual disabilities (ID) have many comorbidities but experience inequities in access to health care. National Health Service England uses an opt-in incentive scheme to encourage annual health checks of patients with ID in primary care. We investigated whether the first 3 years of the programme had improved health care of people with ID. METHODS We did a longitudin...
BACKGROUND High C-reactive protein (CRP) levels have been associated with higher mortality rate in patients with acute myocardial infarction (AMI). However, it is not known whether inflammation plays a role in the time-course of heart failure (HF) in this clinical setting. Our aim was to study the nature of the relationship between CRP and HF during AMI. METHODS This prospective study was car...
OBJECTIVE If New York City (NYC) residents' unusually high rate of ischemic heart disease (IHD) results from chronic exposure to that city, there might also be an effect of acute exposure among visitors to NYC. We explored this possibility and also whether IHD is reduced among NYC residents dying away from the city. METHODS Using all US death certificates for 1985-1994, we examined (correctin...
هدف: این مطالعه ارتباط عملکرد حرکتی،توجه پایدار و کنترل تکانه را در کودکان مبتلا به اختلال نقص توجه بیش فعالی ((adhdو عادی بررسی و مقایسه کرده است. روش:در این پژوهش توصیفی تحلیلی 21 پسر مبتلا به اختلال adhdو 21 پسر عادی در دامنه سنی 7 تا 10 سال شرکت کردند. عملکرد حرکتی با استفاده از آزمون «کفایت حرکتی برونینکز اوزرتسکی» و توجه پایدار و کنترل تکانه با استفاده از « آزمون عملکرد مداوم» بررسی شد. ...
Objective. improve competency of residents with lysis of adhesion (LOA) and bowel surgery using a porcine model. Study Design. Pig bowel was removed at time of an anatomy laboratory, cleansed, and used to demonstrate surgical techniques and principles of LOA, repair of enterotomy, bowel resection, and anastomosis. Participants were surveyed pre- and posttraining session using 10 point Likert sc...
INTRODUCTION Substantial evidence suggests that concerns about postcessation weight gain interfere with cessation efforts. However, it is unclear to what extent weight pretreatment affects smoking-related weight concerns. Given that the prevalence of overweight and obesity among callers to tobacco quitlines mirrors that of the population at large, and that women and obese smokers may be more co...
We aimed to determine the prognostic impact of monosomal karyotype (MK) in acute myeloid leukemia (AML) in the context of the current World Health Organization (WHO) classification and to evaluate the outcome of MK(+) patients after allogeneic HSCT. Of 1058 patients with abnormal cytogenetics, 319 (30%) were MK MK(+). MK(+) patients were significantly older (P = .0001), had lower white blood co...
The lack of diagnostic certainty in some patients makes it difficult to distinguish between primary and secondary forms of thrombocytosis. To augment current diagnostic studies for thrombocytosis, we retrospectively evaluated clinical records and bone marrow trephine specimens of 183 patients with thrombocytosis-164 with essential thrombocythemia (ET), 19 with reactive thrombocytosis (RT)-for b...
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