The purpose of this presentation is to describe a parallel piped oxygen and piped compressed air system for use in inhalation therapy, in patients with chronic pulmonary disease. Intermittent positive pressure breathing (IPPB) with nebulized bronchodilator has been utilized widely in the treatment of conditions associated with disturbances in respiration. Subjective benefits and functional impr...

Patients with obstructive lung disease often require ventilatory support via invasive or noninvasive mechanical ventilation, depending on the severity of the exacerbation. The use of inhaled bronchodilators can significantly reduce airway resistance, contributing to the improvement of respiratory mechanics and patient-ventilator synchrony. Although various studies have been published on this to...

The ventilatory effects of prolonged oxygen administration were examined in seven dogs during thiopentone anaesthesia. Ventilation, tidal volume (VT), ventilatory rate (f), minute ventilation (VE), inspiratory time (TI), expiratory time (TE), period (Ttot), TI/Ttot and mean inspiratory flow (VT/TI) were measured during the inhalation of room air, after 30 min of oxygen inhalation, and finally a...

Precordial ST-segment mapping was serially applied in the Coronary Care Unit for the study of the effect of oxygen inhalation on the ischemic injury in 17 patients with acute anterior transmural myocardial infarction. A 49-lead ECG system was used. The sum of all ST elevations (ZST) recorded was taken as an index of magnitude of ischemic injury and the number of recording sites showing ST eleva...

The circulatory and metabolic effects of inhalation of oxygen in high concentration were investigated in 50 patients with acute myocardial infarction. The heart rate, arterial blood pressure, cardiac out-put, blood gas tensions, pH, and lactate and pyruvate levels were measured. In general, oxygen inhalation produced a fall in cardiac output and stroke volume and a rise in blood pressure and sy...

Our study aimed to investigate the influence of tissue hypo-oxygenation on the adrenomedullin (ADM) system in vivo. For this purpose, male Sprague-Dawley rats were exposed to normobaric hypoxia (8% oxygen) or to functional anemia [0.1% carbon monoxide (CO)] or to cobalt chloride (60 mg/kg) for 6 h. Messenger RNA levels for ADM and its receptor (ADM-R) were assessed in diverse organs by RNase pr...

OBJECTIVES We sought to determine whether or not inhaled nitric oxide (NO) could improve hemodynamic function in patients with right ventricular myocardial infarction (RVMI) and cardiogenic shock (CS). BACKGROUND Inhaled NO is a selective pulmonary vasodilator that can decrease right ventricular afterload. METHODS Thirteen patients (7 males and 6 females, age 65 +/- 3 years) presenting with...

Hypoxic Pulmonary Vasoconstriction (HPV) was first reported by Bindsley et al. in adult patients and was managed using double lumen catheters to ventilate one lung with 100% oxygen and the other with 95% N2 and 5% oxygen during intravenous barbiturate and fentanyl anesthesia. However, ‘‘HPV inhibition’’ has predominantly been attributed to the use of inhalation agents and is considered as a cau...

hypoxemia under certain conditions. However, the relationship between pulmonary anesthetic administration and HPV remains controversial. In conclusion, global effects of inhalation induction with sevoflurane at high concentrations may cause oxygen desaturation in lungs that are normally ventilated with 100% oxygen, potentially resulting in global inhibition of HPV. However, these conditions may...

BACKGROUND The influence of multiple gestation on the occurrence of retinopathy of prematurity (ROP) is still not completely understood. OBJECTIVES To verify the incidence of any stage of ROP and threshold ROP in singletons and in multiple gestation among preterm infants. METHODS This was an institutional, prospective, and descriptive cohort study, which included preterm newborns with birth...