The collision-induced dissociations are reported for Cu(II) complexes containing 1,4,7-triazacyclononane (tacn) as the auxiliary ligand and a peptide containing one cystine residue. For six of the complexes examined, cleavage of the S-S bond in the peptide was the dominant fragmentation pathway. The exceptions were for complexes containing the largest peptides, (GlyCys'Gly)(2) and (GlyGlyCys')(...

Heme proteins, which consist of an iron ion centrally coordinated to four nitrogens in a porphyrin ring, contain an axial, amino acid ligand that can alter the function of the active site, affecting the binding of the oxygen-containing complexes. Several studies have been conducted to investigate the binding abilities of O2, CO, and NO to ferrous heme. In a theoretical study, Rydberg et. al. in...

Hydrocarbone diamantane has been shown to be a specific substrate with a high affinity for the binding site of PB-inducible cytochrome P-450 2B1 (Hodek et al. 1988). Using a difference spectroscopy approach, a battery of diamantane analogues and diamantane oxygen containing derivatives were examined for their interaction with P-450 2B1 active site. Of the compounds (diamantane and its analogues...