BACKGROUND Oxygen may damage the lung directly via generation of reactive oxygen species (ROS) or indirectly via the recruitment of inflammatory cells, especially neutrophils. Overexpression of extracellular superoxide dismutase (EC-SOD) has been shown to protect the lung against hyperoxia in the newborn mouse model. The CXC-chemokine receptor antagonist (Antileukinate) successfully inhibits ne...

C60 fullerene (C60) is a nano-pollutant that can damage the respiratory system. Eugenol exhibits significant anti-inflammatory and antioxidant properties. We aimed to investigate time course of emulsion-induced pulmonary spermatic harms, as well effect eugenol on emulsion toxicity. The first group mice (protocol 1) received intratracheally (1.0 mg/kg BW) or vehicle were tested at 12, 24, 72 96 ...

objective(s): exposing to stress may be associated with increased production of reactive oxygen species (ros). therefore, high level of oxidative stress may eventually give rise to accumulation of oxidative damage and development of numerous neurodegenerative diseases. it has been presented that brain-derived neurotrophic factor (bdnf) supports neurons against various neurodegenerative conditio...

lung contusion is an entity involving injury to the alveolar capillaries, without any tear or cut in the lung tissue. this results in accumulation of blood and other fluids within the lung tissue. the excess fluid interferes with gas exchange leading to hypoxia. the pathophysiology of lung contusion includes ventilation/perfusion mismatching, increased intrapulmonary shunting, increased lung wa...

In epidemiologic studies, high intake of β-cryptoxanthin has been associated with a decreased risk of lung cancer, particularly among current smokers. However, data are not available from well-controlled animal studies to examine the effects of β-cryptoxanthin on cigarette smoke-induced lung lesions, and the biological mechanisms by which β-cryptoxanthin might affect lung carcinogenesis. We eva...

In epidemiologic studies, high intake of b-cryptoxanthin has been associated with a decreased risk of lung cancer, particularly among current smokers. However, data are not available from well-controlled animal studies to examine the effects of b-cryptoxanthin on cigarette smoke-induced lung lesions, and the biological mechanisms by which b-cryptoxanthin might affect lung carcinogenesis. We eva...

Paraquat (PQ) is a well-known pneumotoxicant and provides an established model of oxidative stress. This study focused on the transcriptional response to PQ-driven oxidative stress in rat lungs during an early phase post-injection. Rats were sacrificed at 3 h and 24 h after PQ injection (i.p., 20 mg/ kg b.w.), and at 3 h after a second injection (i.p., 20 mg/kg b.w.). The left lungs were rapidl...