Angiogenesis is essential for endometrial growth and repair, and disruption of this process may lead to common gynecological disorders, including menorrhagia and endometriosis. We have recently shown that expression of vascular endothelial growth factor (VEGF)-A and its two main receptors, VEGFR-1 and -2, is increased in idiopathic menorrhagia (IM). The aim of this study was to determine the ex...

This study was undertaken to determine local GPs' current management of menorrhagia, prior to the release of the Royal College of Obs tetricians and Gynaecologists' (RCOG) guideline on the initial management of menorrhagia. A postal questionnaire was sent to 204 GPs in the Forth Valley area. An 84% (n = 173) response rate was recorded. Responses were compared with RCOG guideline recommendations...

BACKGROUND The presence of aromatase and cyclooxygenase-2 (Cox-2) expression was investigated in the endometrium of patients with idiopathic menorrhagia or adenomyosis. The effect of oral contraceptives administered in extended regimens on the endometrial expression of these enzymes was also investigated. METHODS AND RESULTS Aromatase expression was detected by immunohistochemistry in the end...

Menorrhagia affects approximately 15% of all women, often without identifiable cause. Endometrial spiral arterioles are believed to play a major role in controlling menstruation, and are a major site of menstrual loss. We postulate that alterations in the growth and development of spiral arterioles, particularly the vascular smooth muscle cells (VSMC), may contribute to menorrhagia. We examined...

Objective: The goal of this study is to evaluate the prevalence of Chlamydial endometritis in women with menorrhagia attending Ain Shams University Maternity Hospital. Design: Cross-sectional study. Setting: Ain Shams Maternity teaching hospital. Patients and methods: 300 women were divided randomly into two equal arms of 150 women in each one. Intervention: Patients admitted through the recept...

background: the term dysfunctional uterine bleeding(dub) refers to any abnormal bleeding from the uterus, unassociated with tumour, inflammation and pregnancy. the histological diagnosis of dub is very essential for adequate management especially in perimenopausal and postmenopausal females. the present study was undertaken with the aim of evaluating dub in various age groups, carry out histopa...

A 29 year old woman presented with menorrhagia secondary to hypothyroidism. Subsequent investigation confirmed the presence of a lingual thyroid. Features of cretinism were present despite the late presentation. This unusual case is discussed with reference to previous publications.